Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers

In a longitudinal study of seropositive and seronegative health care workers undergoing asymptomatic and symptomatic SARS-CoV-2 testing, the presence of anti-spike or anti-nucleocapsid IgG antibodies was associated with a substantially reduced risk of SARS-CoV-2 reinfection in the ensuing 6 months.

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 384; no. 6; pp. 533 - 540
Main Authors:	Lumley, Sheila F, O’Donnell, Denise, Stoesser, Nicole E, Matthews, Philippa C, Howarth, Alison, Hatch, Stephanie B, Marsden, Brian D, Cox, Stuart, James, Tim, Warren, Fiona, Peck, Liam J, Ritter, Thomas G, de Toledo, Zoe, Warren, Laura, Axten, David, Cornall, Richard J, Jones, E. Yvonne, Stuart, David I, Screaton, Gavin, Ebner, Daniel, Hoosdally, Sarah, Chand, Meera, Crook, Derrick W, O’Donnell, Anne-Marie, Conlon, Christopher P, Pouwels, Koen B, Walker, A. Sarah, Peto, Tim E.A, Hopkins, Susan, Walker, Timothy M, Jeffery, Katie, Eyre, David W
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 11-02-2021
Subjects:	Adolescent Adult Age Aged Aged, 80 and over Antibodies Antibodies, Viral - blood Asymptomatic Calendars Coronavirus Nucleocapsid Proteins - immunology Coronaviruses COVID-19 COVID-19 - diagnosis COVID-19 - epidemiology COVID-19 - immunology COVID-19 Nucleic Acid Testing COVID-19 Serological Testing Disease transmission Female Firing rate Gender Health care Health Personnel Humans Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology Incidence Infections Investigations Longitudinal Studies Male Medical personnel Middle Aged Nucleocapsids Original Pandemics Polymerase Chain Reaction Recurrence SARS-CoV-2 - immunology SARS-CoV-2 - isolation & purification Seroconversion Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - immunology United Kingdom Workers Young Adult United Kingdom United Kingdom > UK
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Description
Summary:	In a longitudinal study of seropositive and seronegative health care workers undergoing asymptomatic and symptomatic SARS-CoV-2 testing, the presence of anti-spike or anti-nucleocapsid IgG antibodies was associated with a substantially reduced risk of SARS-CoV-2 reinfection in the ensuing 6 months.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 A complete list of members of the Oxford University Hospitals Staff Testing Group is provided in the Supplementary Appendix, available at NEJM.org.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2034545