Prognostic Role of Alveolar-Arterial Oxygen Pressure Difference in Acute Pulmonary Embolism

• Published in: Circulation Journal Vol. 70; no. 12; pp. 1611 - 1616
• Main Authors: Hsu, Jen Te, Chu, Chi Ming, Chang, Shih Tai, Cheng, Hui Wen, Cheng, Nye Jan, Ho, Wan-Ching, Chung, Chang Min
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 2006
• Subjects: Acute pulmonary embolism; Aged; Aged, 80 and over; Alveolar - arterial oxygen pressure difference; Arterial - alveolar oxygen tension ratio; Arteries - physiopathology; Blood Gas Analysis; Female; Humans; Hypoxia - physiopathology; Male; Middle Aged; Oxygen - blood; Predictive Value of Tests; Pressure; Prognosis; Pulmonary Alveoli - blood supply; Pulmonary Alveoli - physiopathology; Pulmonary Embolism - diagnosis; Pulmonary Embolism - mortality; Retrospective Studies; Thrombocytopenia - physiopathology
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.70.1611

Background This study investigated the utility of the alveolar - arterial oxygen pressure difference (AaDO 2) in predicting the short-term prognosis of acute pulmonary embolism (PE). Methods and Results This study retrospectively enrolled 114 consecutive patients with acute PE, diagnosed by either spiral computed tomography or high probability ventilation - perfusion lung scans. During the first 24 h of admission, all patients had initial artery blood gas collected under room air. Patient exclusion criteria were chronic lung disease, septic emboli, and moderate and low probability lung scans. Patients were assigned to 2 groups based on either 30-day death or a 30-day composite event. Receiver operating characteristic analyses was used to determine the AaDO2 cut-off value for predicting primary and composite endpoints. Statistical analysis demonstrated significant differences in AaDO2 between the 30-day composite endpoint group and the 30-day composite event-free survival group (p=0.012). The AaDO2 had a strong trend between the 30-day death group and the survival group (p=0.062). The best cut-off value for AaDO2 was 53 mmHg and using this, the positive predictive value for 30-day death was 25% and the negative predictive value was 92%. For the 30-day composite endpoint, the positive predictive value for AaDO2 was 35%, and the negative predictive value was 84%. In this study, thrombocytopenia was also an indicator of poor prognosis for patients with acute PE. Conclusion The AaDO2 measurement is a highly useful and simple measurement for predicting short-term prognosis in patients with acute PE. It has high negative predictive value and moderate positive predictive value for 30-day death and 30-day composite event. Aggressive thrombolytic treatment strategies should be considered for patients with an initial poor prognostic parameter (ie, AaDO2 ≥53 mmHg). (Circ J 2006; 70: 1611 - 1616)