A study on the bio-applicability of aqueous-dispersed van der Waals 1-D material Nb2Se9 using poloxamer

• Published in: Scientific reports Vol. 11; no. 1; p. 176
• Main Authors: Chae, Sudong, Oh, Seungbae, Choi, Kyung Hwan, Lee, Jin Woong, Jeon, Jiho, Liu, Zhixiang, Wang, Cong, Lim, Changmo, Dong, Xue, Woo, Chaeheon, Asghar, Ghulam, Shi, Liyi, Kang, Joohoon, Kim, Sung Jae, Song, Si Young, Lee, Jung Heon, Yu, Hak Ki, Choi, Jae-Young
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08-01-2021; Nature Publishing Group; Nature Portfolio
• Subjects: 639/301/357/551; 639/301/54/994; Adaptability; Biocompatibility; Cell proliferation; Humanities and Social Sciences; Hydrophobic surfaces; Hydrophobicity; Materials science; Molecular weight; multidisciplinary; Nanomaterials; Nanotechnology; Nanowires; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-80730-2

In this research, dispersion of a new type of one-dimensional inorganic material Nb
2
Se
9
, composed of van der Waals bonds, in aqueous solution for bio-application study were studied. To disperse Nb
2
Se
9
, which exhibits hydrophobic properties in water, experiments were carried out using a block copolymer (poloxamer) as a dispersant. It was confirmed that PPO, the hydrophobic portion of Poloxamer, was adsorbed onto the surface of Nb
2
Se
9
, and PEO, the hydrophilic portion, induced steric hinderance to disperse Nb
2
Se
9
to a size of 10 nm or less. To confirm the adaptability of muscle cells C2C12 to the dispersed Nb
2
Se
9
using poloxamer 188 as dispersant, a MTT assay and a live/dead assay were performed, demonstrating improvement in the viability and proliferation of C2C12 cells.