A proposal for an alternative quality control test procedure for inactivated vaccines against food-and-mouth disease virus

• Published in: Vaccine Vol. 31; no. 9; pp. 1349 - 1352
• Main Authors: Molin-Capeti, K.C, Sepulveda, L, Terra, F, Torres-Pioli, M.F, Costa-Casagrande, T, França, S.C, Thomaz-Soccol, V
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 18-02-2013; Elsevier; Elsevier Limited
• Subjects: Allergy and Immunology; Alternative quality control; animal models; Animals; antibodies; Antibodies, Viral - blood; Antigens; Applied microbiology; Biological and medical sciences; Biological Assay - methods; Brazil; Cattle; ELISA; Enzymes; Experiments; food availability; Foot & mouth disease; Foot-and-mouth disease; Foot-and-Mouth Disease - immunology; Foot-and-Mouth Disease - prevention & control; Foot-and-mouth disease virus; Foot-and-Mouth Disease Virus - immunology; Fundamental and applied biological sciences. Psychology; humoral immunity; immune response; inactivated vaccines; Laboratory animals; Mice; Mice, Inbred BALB C; Microbiology; product testing; Quality Control; serotypes; Technology, Pharmaceutical - methods; Technology, Pharmaceutical - standards; titration; vaccination; Vaccine; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Inactivated - immunology; viral proteins; Viral Vaccines - immunology; viruses; Brazil; FELASA; foot-and-mouth disease; EPP; food-and-mouth disease virus; MAPA; percentage of inhibition; Pan American Foot-and-Mouth Disease Center; LFB; PANAFTOSA; Vaccine; DPV; expected percentage of protection; Brazilian Ministry of Agriculture; Federation of European Laboratory Animal Science Associations; liquid-phase blocking; FMDV; PI; day(s) post-vaccination; FMD; Alternative quality control; ELISA; Foot-and-mouth disease; Infection; Foot and mouth disease; Viral disease; Quality control; Veterinary; ELISA assay; Food; Inactivated strain
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2012.12.001

Highlights ► We propose an alternative model for quality control to vaccine for the bovine FMD. ► The results obtained were compared against previously known results of FMD vaccine response in cattle. ► This would represent time and cost savings, and easier handling.