Microencapsulated ferrous sulfate to fortify cow milk: Absorption and distribution in mice

• Published in: Journal of Nutritional Science and Vitaminology Vol. 44; no. 3; pp. 381 - 389
• Main Authors: Boccio, J.R. (University of Buenos Aires (Argentina)), Zubillaga, M.B, Caro, R, Lysionek, A.E, Salgueiro, M.J, Calmanovici, G.P, Sarabia, M.I, Weill, R
• Format: Journal Article
• Language: English
• Published: Tokyo Center for Academic Publications Japan 01-06-1998
• Subjects: ABSORCION DE SUSTANCIAS NUTRITIVAS; Absorption; ABSORPTION DE SUBSTANCES NUTRITIVES; Animals; Biological and medical sciences; Bone and Bones - metabolism; COMPLEMENTATION; COW MILK; Drug Compounding; ENRIQUECIMIENTO DE LOS ALIMENTOS; Feeding. Feeding behavior; Female; Ferrous Compounds - administration & dosage; Ferrous Compounds - pharmacokinetics; FERROUS SULPHATE; FOOD ENRICHMENT; Food, Fortified; fortification; Fundamental and applied biological sciences. Psychology; iron; LAIT DE VACHE; LECHE DE VACA; Liver - metabolism; metabolism; MICE; Milk; Muscles - metabolism; NUTRIENT UPTAKE; RATON; Skin - metabolism; SOURIS; SULFATE FERREUX; SULFATO FERROSO; Tissue Distribution; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Iron sulfate; Rodentia; Metabolism; Inorganic element; Fortified product; Feeding; Vertebrata; Mammalia; Absorption; Mouse; Animal; Cow milk; Body compartment; Microencapsulation; Concentration distribution
• ISSN: 0301-4800; 1881-7742
• DOI: 10.3177/jnsv.44.381

To determine the absorption and biodistribution of iron from microencapsulated ferrous sulfate (SFE-171), used to fortify dairy products with iron, a comparative study in four groups of 30 mice each was carried out. In two of the groups, the absorption of iron from ferrous ascorbate in water (13.1 +- 4.3%) and from ferrous sulfate in water (12.7 +- 3.9%) was determined and taken as reference standards. In the third group the iron absorption from SFE-171 in milk was determined, giving a value of 12.1 +- 4.2%, which statistically does not differ from the data obtained with either reference standard. In the fourth group, the absorption of iron from ferrous sulfate in milk showed a value of 7.7 +- 3.4%, which statistically differs with a p0.01 from the data corresponding to the other three groups. The biodistribution studies showed that the iron from SFE-171 follows the same metabolic pathway as the iron from the reference standards thus, giving a higher radioactivity percentage and radioactivity concentration in organs or systems, principally blood, that are closely related to iron metabolism. Our studies allow us to conclude that the iron from SFE-171 in milk follows the same behavior as the nonhemic iron, with a higher absorption than that of ferrous sulfate in milk