The Interplay of Oxidative Stress and ROS Scavenging: Antioxidants as a Therapeutic Potential in Sepsis

• Published in: Vaccines (Basel) Vol. 10; no. 10; p. 1575
• Main Authors: Kumar, Sanni, Saxena, Juhi, Srivastava, Vijay Kumar, Kaushik, Sanket, Singh, Himadri, Abo-EL-Sooud, Khaled, Abdel-Daim, Mohamed M, Jyoti, Anupam, Saluja, Rohit
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 20-09-2022; MDPI
• Subjects: Analysis; Animal models; antioxidant; Antioxidants; Apoptosis; Binding sites; Biological activity; Care and treatment; Clinical trials; Complications and side effects; Cytokines; Defense mechanisms; Free radicals; Gene expression; Health aspects; Human pathology; Immune response; Immune system; Inflammation; Kinases; Lipid peroxidation; Microorganisms; Mortality; Neutrophils; Nitric oxide; Oxidants; Oxidative stress; Oxidizing agents; Pathogenesis; Pathology; Patients; Reactive oxygen species; Review; ROS; Scavenging; Sepsis; Signal transduction; Signaling; Streptococcus infections; India
• ISSN: 2076-393X; 2076-393X
• DOI: 10.3390/vaccines10101575

Oxidative stress resulting from the disproportion of oxidants and antioxidants contributes to both physiological and pathological conditions in sepsis. To combat this, the antioxidant defense system comes into the picture, which contributes to limiting the amount of reactive oxygen species (ROS) leading to the reduction of oxidative stress. However, a strong relationship has been found between scavengers of ROS and antioxidants in preclinical in vitro and in vivo models. ROS is widely believed to cause human pathology most specifically in sepsis, where a small increase in ROS levels activates signaling pathways to initiate biological processes. An inclusive understanding of the effects of ROS scavenging in cellular antioxidant signaling is essentially lacking in sepsis. This review compiles the mechanisms of ROS scavenging as well as oxidative damage in sepsis, as well as antioxidants as a potent therapeutic. Direct interaction between ROS and cellular pathways greatly affects sepsis, but such interaction does not provide the explanation behind diverse biological outcomes. Animal models of sepsis and a number of clinical trials with septic patients exploring the efficiency of antioxidants in sepsis are reviewed. In line with this, both enzymatic and non-enzymatic antioxidants were effective, and results from recent studies are promising. The usage of these potent antioxidants in sepsis patients would greatly impact the field of medicine.