Ginsenoside Rg12, a new dammarane-type triterpene saponin from Panax ginseng root

• Published in: Journal of ginseng research Vol. 41; no. 4; pp. 531 - 533
• Main Authors: Lee, Dong Gu, Lee, Jaemin, Cho, Ik-Hyun, Kim, Hak-Jae, Lee, Sang-Won, Kim, Young-Ock, Park, Chun-Gun, Lee, Sanghyun
• Format: Journal Article
• Language: English
• Published: Korea (South) Elsevier B.V 01-10-2017; 고려인삼학회; Elsevier
• Subjects: dammarane-type triterpene saponin; ginsenoside Rg12; Panax ginseng; white ginseng; 기타의약학; dammarane-type triterpene saponin; Panax ginseng; ginsenoside Rg12; white ginseng
• ISSN: 1226-8453; 2093-4947
• DOI: 10.1016/j.jgr.2016.10.002

Panax ginseng has been used as Korean medicine for various diseases. It has antioxidant, hypotensive, sedative, analgesic, and endocrine activities. Dammarane-type triterpenes from the plant have various beneficial effects.
A dammarane-type triterpene saponin was isolated from P. ginseng root through chromatography such as repeated column chromatography and medium pressure liquid chromatography.
New dammarane-type triterpene saponin was isolated for the first time from nature. The structure was elucidated as ginsenoside Rg12 (1) based on spectral data. There may be good materials from P. ginseng for the development of industrial applications such as nutraceutical, pharmaceutical, and cosmeceutical purposes.