Antiphospholipid antibodies among pregnant women with recurrent fetal wastage in a tertiary hospital in Northern Nigeria

• Published in: Annals of African medicine Vol. 15; no. 3; pp. 133 - 137
• Main Authors: Abdullahi, Zubaida, Abdul, Mohammmed, Aminu, Sirajo, Musa, Bolanle, Amadu, Lawal, Jibril, El-Bashir
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow Publications 01-07-2016; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd
• Subjects: Abortion, Habitual - epidemiology; Abortion, Habitual - immunology; Adolescent; Adult; Antibodies, Anticardiolipin - blood; Antibodies, Antiphospholipid - blood; Antiphospholipid antibodies; Blood Coagulation Tests; Case-Control Studies; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Fetal Death; Health aspects; Humans; Immunoglobulin G - blood; Immunoglobulin M - blood; Lupus Coagulation Inhibitor - blood; Nigeria - epidemiology; Original; Physiological aspects; Pregnancy; Pregnancy Complications - epidemiology; Pregnancy Complications - immunology; Pregnancy Outcome; Pregnant women; Prevalence; Tertiary Care Centers; Nigeria; Antenatal clients; lupus anticoagulant; anticardiolipin antibody; antiphospholipid antibodies; recurrent pregnancy loss
• ISSN: 1596-3519; 0975-5764
• DOI: 10.4103/1596-3519.188894

Context: The association between antiphospholipid antibodies (APAs) and pregnancy loss has been established and now considered as a treatable cause of pregnancy loss. Data on the prevalence of APA in patients with recurrent pregnancy loss are scarce in our environment.
Aims: To determine the prevalence of APA in pregnant women with and without recurrent fetal wastage.
Settings and Design: Antenatal clinic of Ahmadu Bello University Teaching Hospital, Zaria, Nigeria. A cross-section analytical study.
Subjects and Methods: Eighty-five antenatal patients with recurrent fetal loss (cases) and an equal number of antenatal patients without recurrent fetal loss (control) matched for age were studied. Their sociodemographic data obtained and blood samples analyzed for lupus anticoagulant (LA) using activated partial thromboplastin time, direct Russel′s viper venom time, hexagonal phospholipids, and IgG anticardiolipin antibody (ACA) using enzyme-linked immunosorbent assay.
Statistical Analysis Used: Data were analyzed with Statistical Package for Social Sciences (version 17) by univariate analysis and Chi-square test.
Results: The age range of the patients was 18-42 years with a median of 30 years. The prevalence of APA was 14.1% and 4.7% among the cases and controls, respectively. The prevalence of LA was 7.1% and 1.2% among the cases and controls, respectively, whereas ACA was 8.2% and 3.5%, respectively. However, one of the cases was positive for both APA and ACA, giving a prevalence of 1.2%.
 Conclusions: The prevalence of APA among antenatal patients with recurrent pregnancy loss was, at least, 3 times higher than that of normal antenatal clients. APA should be included in the investigation protocol of women with recurrent fetal wastages in our setting.