IL-18 and Cutaneous Inflammatory Diseases

• Published in: International journal of molecular sciences Vol. 16; no. 12; pp. 29357 - 29369
• Main Authors: Lee, Ji Hyun, Cho, Dae Ho, Park, Hyun Jeong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09-12-2015; MDPI
• Subjects: alopecia areata; Animals; atopic dermatitis; contact dermatitis; Cytokines; drug eruption; fibrosis; Graft vs Host Disease - immunology; Graft vs Host Disease - metabolism; graft-versus-host disease; Humans; IL-18; Immune system; Immunomodulation; Inflammation Mediators - physiology; Inflammatory diseases; Interferon; Interleukin-18 - physiology; lupus erythematosus; psoriasis; Review; Signal Transduction; skin disease; Skin diseases; Skin Diseases - immunology; Skin Diseases - metabolism; skin tumor; urticaria; drug eruption; lupus erythematosus; IL-18; psoriasis; urticaria; contact dermatitis; atopic dermatitis; skin disease; skin tumor; fibrosis; alopecia areata; graft-versus-host disease
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms161226172

Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities.