Neonatal manipulation of oxytocin prevents lipopolysaccharide-induced decrease in gene expression of growth factors in two developmental stages of the female rat

• Published in: Neuropeptides (Edinburgh) Vol. 48; no. 5; pp. 281 - 286
• Main Authors: Bakos, Jan, Lestanova, Zuzana, Strbak, Vladimir, Havranek, Tomas, Bacova, Zuzana
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-10-2014
• Subjects: Advanced Basic Science; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor - genetics; Development; Encephalitis - chemically induced; Encephalitis - metabolism; Endocrinology & Metabolism; Female; Gene Expression - drug effects; Hippocampus - drug effects; Hippocampus - metabolism; Lipopolysaccharides; Male; MAP-2; Microtubule-Associated Proteins - genetics; Nerve Growth Factor - genetics; Nerve Growth Factors - genetics; Nerve Tissue Proteins - genetics; Nestin; Nestin - genetics; Neuronal Plasticity; Neurotrophic factors; Oxytocin; Oxytocin - pharmacology; Rats; Rats, Wistar; RNA, Messenger - metabolism; Development; Nestin; MAP-2; Oxytocin; Neurotrophic factors
• ISSN: 0143-4179; 1532-2785
• DOI: 10.1016/j.npep.2014.06.004

Highlights • Neonatal oxytocin did not prevent decrease of body weight in LPS treated animals. • Oxytocin increased BDNF mRNA in 21-day and 2-month old rats of both sexes. • Oxytocin enhanced gene expression of MAP-2 and nestin in 21-day old males. • Oxytocin treatment prevented LPS induced decrease in the gene expression of growth factors in females.