Neuroendocrine regulation of inflammation

• Published in: Seminars in immunology Vol. 26; no. 5; pp. 357 - 368
• Main Authors: Padro, Caroline J, Sanders, Virginia M
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-10-2014
• Subjects: Adrenergic receptor; Allergy and Immunology; Asthma - genetics; Asthma - immunology; Asthma - metabolism; Asthma - pathology; Beta2-adrenergic receptor; Cytokines - genetics; Cytokines - immunology; Dendritic Cells - immunology; Dendritic Cells - metabolism; Dendritic Cells - pathology; Gene Expression Regulation; Homeostasis - genetics; Homeostasis - immunology; Humans; Immune System - metabolism; Lymphocytes - immunology; Lymphocytes - metabolism; Lymphocytes - pathology; Neuroimmune; Norepinephrine; Norepinephrine - genetics; Norepinephrine - immunology; Pneumonia, Bacterial - genetics; Pneumonia, Bacterial - immunology; Pneumonia, Bacterial - metabolism; Pneumonia, Bacterial - pathology; Receptors, Adrenergic, beta-2 - genetics; Receptors, Adrenergic, beta-2 - immunology; Signal Transduction; Spinal Cord Injuries - genetics; Spinal Cord Injuries - immunology; Spinal Cord Injuries - metabolism; Spinal Cord Injuries - pathology; Stress; Stress, Physiological; Sympathetic nervous system; Sympathetic Nervous System - immunology; norepinephrine; TNFα; Tregulatory; G-protein coupled receptor kinases; GRKs; dendritic cells; BMDC; Neuroimmune; PALS; G-protein coupled receptors; Beta2-adrenergic receptor; PKA; severe combined immunodeficiency; rheumatoid arthritis; 2,4,6-trinitrochlorobenzene; central nervous system; RA; BM-derived DCs; periarteriolar lymphatic sheath; Gα s; NE; HPA; Gα i; TCNB; GTP-binding proteins; CNS; BM; cytotoxic T lymphocytes; stimulatory G-protein; DCs; GPCRs; adrenergic receptors; SNS; protein kinase A; scid; spinal cord injury; hypothalamic-pituitary-adrenal; ARs; sympathetic nervous system; T reg; bone marrow; Stress; APC; tumor necrosis factor-α; SCI; antigen presenting cell; CTL; Adrenergic receptor; G-proteins; inhibitory G-protein; Gαi; Treg; Gαs; Sympathetic nervous system; Norepinephrine
• ISSN: 1044-5323; 1096-3618
• DOI: 10.1016/j.smim.2014.01.003

Highlights • Sympathetic nerve fibers penetrate the parenchyma of lymphoid organs. • Antigen exposure leads to norepinephrine release from nerve terminals. • Norepinephrine binds to adrenergic receptors expressed on immune cells. • Adrenergic receptor signaling in immune cells modulates cell activity and function.