Inhibition by nociceptin of neurogenic inflammation and the release of SP and CGRP from sensory nerve terminals

Pretreatment with the novel neuropeptide nociceptin (20 μg kg−1, i.p.) caused an inhibition of plasma extravasation evoked by antidromic stimulation of the saphenous nerve or by topical application of 1% mustard oil on the skin of the acutely denervated hindleg of the rat. In contrast, it did not af...

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Bibliographic Details
Published in:	British journal of pharmacology Vol. 121; no. 4; pp. 613 - 615
Main Authors:	Helyes, Zsuzsanna, Németh, József, Pintér, Erika, Szolcsányi, János
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-06-1997 Nature Publishing
Subjects:	Animals Biological and medical sciences Bradykinin Calcitonin Gene-Related Peptide - metabolism calcitonin gene‐related peptide Capillary Permeability - drug effects Electric Stimulation Fundamental and applied biological sciences. Psychology inflammation Inflammation - drug therapy Inflammation - etiology neurogenic inflammation Nociceptin Opioid Peptides - pharmacology primary afferent neurones rat trachea Rats Sensory Receptor Cells - drug effects Sensory Receptor Cells - metabolism Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors Special Report substance P Substance P - metabolism Trachea - drug effects Trachea - metabolism Vertebrates: nervous system and sense organs Nociception Rat Substance P Peptide hormone Rodentia Central nervous system Calcitonine gene related peptide Respiratory system In vitro Neuropeptide Mechanism In vivo Vertebrata Regulation(control) Mammalia Animal Sensory nerve Sensory neuron Neurogenic inflammation Trachea Release Brain (vertebrata)
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Summary:	Pretreatment with the novel neuropeptide nociceptin (20 μg kg−1, i.p.) caused an inhibition of plasma extravasation evoked by antidromic stimulation of the saphenous nerve or by topical application of 1% mustard oil on the skin of the acutely denervated hindleg of the rat. In contrast, it did not affect non‐neurogenic inflammation evoked by s.c. injection of bradykinin after chronic denervation. Release of substance P (SP) and calcitonin gene‐related peptide (CGRP) from rat isolated tracheae in response to electrical field stimulation was diminished by nociceptin (100 nM). It is concluded that nociceptin inhibits the release of sensory neuropeptides from terminals of nociceptive neurones. British Journal of Pharmacology (1997) 121, 613–615; doi:10.1038/sj.bjp.0701209
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0007-1188 1476-5381
DOI:	10.1038/sj.bjp.0701209