A wobbly road to drug resistance in melanoma: tRNA‐modifying enzymes in translation reprogramming

Alterations in transcript‐specific translation are emerging as a driver of cellular transformation and cancer etiology. A new study provides evidence for enhanced codon‐dependent translation of hypoxia‐inducible factor 1α in promoting glycolytic metabolism and drug resistance in melanoma cells. This...

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Bibliographic Details
Published in:	The EMBO journal Vol. 37; no. 15
Main Authors:	McMahon, Mary, Ruggero, Davide
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-08-2018 Blackwell Publishing Ltd John Wiley and Sons Inc
Subjects:	Cancer Codon Drug metabolism Drug Resistance EMBO03 EMBO24 Enzymes Etiology Glycolysis Humans Hypoxia Melanoma Metabolism News & Views Phosphorylation Ribonucleic acid RNA RNA, Transfer Transcription Transfer RNA Translation tRNA Views
Online Access:	Get full text
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