A wobbly road to drug resistance in melanoma: tRNA‐modifying enzymes in translation reprogramming

A wobbly road to drug resistance in melanoma: tRNA‐modifying enzymes in translation reprogramming

Alterations in transcript‐specific translation are emerging as a driver of cellular transformation and cancer etiology. A new study provides evidence for enhanced codon‐dependent translation of hypoxia‐inducible factor 1α in promoting glycolytic metabolism and drug resistance in melanoma cells. This...

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Bibliographic Details
Published in:The EMBO journal Vol. 37; no. 15
Main Authors: McMahon, Mary, Ruggero, Davide
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01-08-2018
Blackwell Publishing Ltd
John Wiley and Sons Inc
Subjects:
Cancer
Codon
Drug metabolism
Drug Resistance
EMBO03
EMBO24
Enzymes
Etiology
Glycolysis
Humans
Hypoxia
Melanoma
Metabolism
News & Views
Phosphorylation
Ribonucleic acid
RNA
RNA, Transfer
Transcription
Transfer RNA
Translation
tRNA
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Summary:Alterations in transcript‐specific translation are emerging as a driver of cellular transformation and cancer etiology. A new study provides evidence for enhanced codon‐dependent translation of hypoxia‐inducible factor 1α in promoting glycolytic metabolism and drug resistance in melanoma cells. This specialized translation reprogramming relies, in part, on mTORC2‐mediated phosphorylation of enzymes modifying the wobble position of the transfer RNA anticodon. Graphical Abstract A new study shows that codon‐dependent translation regulation of HIF1α couples glycolytic metabolism to drug resistance in skin cancer.
Bibliography:ObjectType-Article-2
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See also: https://doi.org/10.1038/s41586-018-0243-7 (June 2018)
ISSN:0261-4189
1460-2075
DOI:10.15252/embj.201899978