A wobbly road to drug resistance in melanoma: tRNA‐modifying enzymes in translation reprogramming
Alterations in transcript‐specific translation are emerging as a driver of cellular transformation and cancer etiology. A new study provides evidence for enhanced codon‐dependent translation of hypoxia‐inducible factor 1α in promoting glycolytic metabolism and drug resistance in melanoma cells. This...
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| Published in: | The EMBO journal Vol. 37; no. 15 |
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| Main Authors: | , |
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| Language: | English |
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Nature Publishing Group UK
01-08-2018
Blackwell Publishing Ltd John Wiley and Sons Inc |
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| Abstract | Alterations in transcript‐specific translation are emerging as a driver of cellular transformation and cancer etiology. A new study provides evidence for enhanced codon‐dependent translation of hypoxia‐inducible factor 1α in promoting glycolytic metabolism and drug resistance in melanoma cells. This specialized translation reprogramming relies, in part, on mTORC2‐mediated phosphorylation of enzymes modifying the wobble position of the transfer RNA anticodon.
Graphical Abstract
A new study shows that codon‐dependent translation regulation of HIF1α couples glycolytic metabolism to drug resistance in skin cancer. |
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| AbstractList | Alterations in transcript‐specific translation are emerging as a driver of cellular transformation and cancer etiology. A new study provides evidence for enhanced codon‐dependent translation of hypoxia‐inducible factor 1α in promoting glycolytic metabolism and drug resistance in melanoma cells. This specialized translation reprogramming relies, in part, on
mTORC
2‐mediated phosphorylation of enzymes modifying the wobble position of the transfer
RNA
anticodon. Alterations in transcript‐specific translation are emerging as a driver of cellular transformation and cancer etiology. A new study provides evidence for enhanced codon‐dependent translation of hypoxia‐inducible factor 1α in promoting glycolytic metabolism and drug resistance in melanoma cells. This specialized translation reprogramming relies, in part, on mTORC2‐mediated phosphorylation of enzymes modifying the wobble position of the transfer RNA anticodon. A new study shows that codon‐dependent translation regulation of HIF1α couples glycolytic metabolism to drug resistance in skin cancer. Alterations in transcript‐specific translation are emerging as a driver of cellular transformation and cancer etiology. A new study provides evidence for enhanced codon‐dependent translation of hypoxia‐inducible factor 1α in promoting glycolytic metabolism and drug resistance in melanoma cells. This specialized translation reprogramming relies, in part, on mTORC2‐mediated phosphorylation of enzymes modifying the wobble position of the transfer RNA anticodon. Alterations in transcript‐specific translation are emerging as a driver of cellular transformation and cancer etiology. A new study provides evidence for enhanced codon‐dependent translation of hypoxia‐inducible factor 1α in promoting glycolytic metabolism and drug resistance in melanoma cells. This specialized translation reprogramming relies, in part, on mTORC2‐mediated phosphorylation of enzymes modifying the wobble position of the transfer RNA anticodon. Graphical Abstract A new study shows that codon‐dependent translation regulation of HIF1α couples glycolytic metabolism to drug resistance in skin cancer. |
| Author | Ruggero, Davide McMahon, Mary |
| AuthorAffiliation | 1 School of Medicine and Department of Urology Helen Diller Family Comprehensive Cancer Center University of California San Francisco CA USA 2 Department of Cellular and Molecular Pharmacology University of California San Francisco CA USA |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29967029$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/ncomms15617 10.1016/j.molcel.2007.09.021 10.1016/j.chembiol.2013.10.015 10.1093/nar/gkh185 10.1038/nature07643 10.1016/j.cell.2015.05.022 10.1016/j.molcel.2006.07.031 10.1016/j.ccr.2012.02.014 10.1016/j.cub.2012.11.031 10.1261/rna.7247705 10.1016/j.cell.2013.06.043 10.1038/s41586-018-0243-7 |
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| SubjectTerms | Cancer Codon Drug metabolism Drug Resistance EMBO03 EMBO24 Enzymes Etiology Glycolysis Humans Hypoxia Melanoma Metabolism News & Views Phosphorylation Ribonucleic acid RNA RNA, Transfer Transcription Transfer RNA Translation tRNA Views |
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| Title | A wobbly road to drug resistance in melanoma: tRNA‐modifying enzymes in translation reprogramming |
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