Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men

• Published in: Nature communications Vol. 8; no. 1; p. 14146
• Main Authors: Blondin, Denis P., Tingelstad, Hans C., Noll, Christophe, Frisch, Frédérique, Phoenix, Serge, Guérin, Brigitte, Turcotte, Éric E, Richard, Denis, Haman, François, Carpentier, André C.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30-01-2017; Nature Publishing Group; Nature Portfolio
• Subjects: 59/78; 631/443/319/1557; 631/443/319/2723; 692/700/1421/1846/2092; 9/10; Body fat; Fatty acids; Glucose; Hormones; Humanities and Social Sciences; Insulin resistance; Metabolism; Metabolites; multidisciplinary; Plasma; Science; Science (multidisciplinary); Variance analysis; Canada
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/ncomms14146

In rodents, brown adipose tissue (BAT) plays an important role in producing heat to defend against the cold and can metabolize large amounts of dietary fatty acids (DFA). The role of BAT in DFA metabolism in humans is unknown. Here we show that mild cold stimulation (18 °C) results in a significantly greater fractional DFA extraction by BAT relative to skeletal muscle and white adipose tissue in non-cold-acclimated men given a standard liquid meal containing the long-chain fatty acid PET tracer, 14(
R
,
S
)-[
18
F]-fluoro-6-thia-heptadecanoic acid (
18
FTHA). However, the net contribution of BAT to systemic DFA clearance is comparatively small. Despite a 4-week cold acclimation increasing BAT oxidative metabolism 2.6-fold, BAT DFA uptake does not increase further. These findings show that cold-stimulated BAT can contribute to the clearance of DFA from circulation but its contribution is not as significant as the heart, liver, skeletal muscles or white adipose tissues.
Brown adipose tissue (BAT) takes up and burns fatty acids for thermogenesis in mice. Here the authors use PET to show that, in humans, cold stimulation increases BAT dietary fatty acid uptake from plasma and oxidative metabolism, although, unlike mice, human BAT takes up less fatty acids than other metabolic tissues.