Hematoporphyrin Monomethyl Ether Photodynamic Therapy of Port Wine Stain: Narrative Review

• Published in: Clinical, cosmetic and investigational dermatology Vol. 16; pp. 1135 - 1144
• Main Authors: Diao, Ping, Han, Chenglong, Li, Xiaoxue, Yang, Yi, Jiang, Xian
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01-01-2023; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Apoptosis; Autophagy; Cancer; Collagen; hmme；pdt; Mutation; Photochemotherapy; Photodynamic therapy; photosensitizer; port wine stain; Review; Skin; Vascular endothelial growth factor; China; PDT; HMME; port wine stain; photodynamic therapy; photosensitizer
• ISSN: 1178-7015; 1178-7015
• DOI: 10.2147/CCID.S401447

Port wine stain (PWS) is a congenital and progressive capillary malformation characterized by structural abnormalities of intradermal capillaries and postcapillary venules. The visible manifestation is often considered a disfigurement and the accompanying social stigma often causes serious emotional and physical impact. Hematoporphyrin monomethyl ether (HMME) is a newly authorized photosensitizer for treating PWS in China. Hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) has successfully treated thousands of Chinese patients with PWS since 2017, and HMME-PDT may be one of the most promising strategies for the treatment of PWS. However, there are few reviews published about the clinical use of HMME-PDT. So in this article, we want to briefly review the mechanism, efficacy evaluation, effectiveness and influencing factors, and the common postoperative reactions and treatment suggestions of HMME-PDT in the treatment of PWS.