Hepatotoxicity by Drugs: The Most Common Implicated Agents

• Published in: International journal of molecular sciences Vol. 17; no. 2; p. 224
• Main Author: Bjornsson, Einar S
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06-02-2016; MDPI
• Subjects: Chemical and Drug Induced Liver Injury - epidemiology; Chemical and Drug Induced Liver Injury - etiology; Databases, Factual; drug-induced liver injury; Drug-Related Side Effects and Adverse Reactions; drugs; hepatotoxicity; Humans; idiosyncratic; Liver diseases; Pharmaceutical Preparations - classification; Pharmacology; Review; Risk; Side effects; Toxicity; Web Browser; drug-induced liver injury; drugs; hepatotoxicity; idiosyncratic
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms17020224

Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox (http://livertox.nlm.nih.gov). According to critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury. Only 48 drugs had more than 50 case reports of DILI. Amoxicillin-clavulanate is the most commonly implicated agent leading to DILI in the prospective series. In a recent prospective study, liver injury due to amoxicillin-clavulanate was found to occur in approximately one out of 2300 users. Drugs with the highest risk of DILI in this study were azathioprine and infliximab.