Increased Serum Cu/Zn SOD in Individuals with Clinical Depression Normalizes After Zinc and Anti-oxidant Therapy

• Published in: Nutrition and metabolic insights Vol. 2010; no. 3; pp. 37 - 42
• Main Author: Russo, A.J.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publishing 01-01-2010; SAGE Publications; Sage Publications Ltd. (UK); Sage Publications Ltd; Libertas Academica
• Subjects: Depression, Mental; Health aspects; Short Report; Superoxide; Cu/Zn SOD; depression; super oxide dismutase; oxidative stress
• ISSN: 1178-6388; 1178-6388
• DOI: 10.4137/NMI.S5044

A.J. RussoResearch Director, Health Research Institute/Pfeiffer Treatment Center, 4575 Weaver Parkway, Warrenville, Illinois 60555. Abstract Aim: To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with clinical depression.Subjects and methods: Serum from 36 individuals diagnosed with clinical depression and 18 healthy controls were tested for Cu/Zn SOD serum concentration using ELISAs.Results: Serum Cu/Zn SOD levels of depressed individuals (both with and without secondary anxiety) were significantly higher than age and gender similar controls. We also found that, post anti-oxidant therapy, Cu/Zn SOD levels normalized to the level of normal healthy controls.Discussion: These results suggest an association between Cu/Zn SOD serum levels and clinical depression.