A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition

• Published in: Journal of pediatric surgery case reports Vol. 3; no. 5; pp. 223 - 226
• Main Authors: Loverdos, Ines, Swan, Marc C, Shekherdimian, Shant, Al-Rasheed, Abdulrahman A, Schneider, Rayfel, Fish, Joel S, Ngan, Bo-Yee, Adeli, Khosrow, Lowe, Mark E, Singh, Vijay P, Sevilla, Wednesday Marie A, Langer, Jacob C, Gonska, Tanja
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01-05-2015; Elsevier
• Subjects: Complicated pancreatitis; Pancreatitis, panniculitis and polyarthritis syndrome; Pediatric pancreatitis; Surgery; PPP; Magnetic Resonance Imaging; Pediatric pancreatitis; MRI; Complicated pancreatitis; Pancreatitis, Panniculitis and Polyarthritis; Pancreatitis, panniculitis and polyarthritis syndrome; panniculitis and polyarthritis syndrome; Pancreatitis
• ISSN: 2213-5766; 2213-5766
• DOI: 10.1016/j.epsc.2015.03.014

Abstract Pancreatitis-Panniculitis-Polyarthritis (PPP) syndrome is rare and its physiopathology unclear. A 6-year old boy suffered of traumatic pancreatitis complicated by PPP syndrome. Extensive investigations demonstrated high levels of pancreatic lipase and fatty acids in the affected peripheral tissues. These findings support the sequence of peripheral lipolysis and fatty acid accumulation inducing tissue inflammation.