Influence of diabetes on ambulation and inflammation in men and women with symptomatic peripheral artery disease

• Published in: Journal of clinical & translational endocrinology Vol. 2; no. 4; pp. 137 - 143
• Main Authors: Gardner, Andrew W, Parker, Donald E, Montgomery, Polly S, Sosnowska, Danuta, Casanegra, Ana I, Ungvari, Zoltan, Csiszar, Anna, Zhang, Sarah X, Wang, Josh J, Sonntag, William E
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01-12-2015; Elsevier
• Subjects: Claudication; Endocrinology & Metabolism; Exercise; Mobility; Peripheral vascular disease; Research Paper; high sensitivity C-reactive protein; Claudication; nuclear factor K-light-chain-enhancer of activated B cells; peripheral artery disease; Mobility; Peripheral vascular disease; ABI; COT; pigment epithelium-derived factor; PWT; NF-κB; PAD; PEDF; Exercise; claudication onset time; ROS; reactive oxygen species; peak walking time; ankle/brachial index; HsCRP; Peripheral Vascular Disease
• ISSN: 2214-6237; 2214-6237
• DOI: 10.1016/j.jcte.2015.08.003

Highlights • Diabetes and sex were correlated with ambulation and inflammation in patients with claudication. • Men with diabetes have worse ambulation than men without diabetes. • Women with diabetes have greater inflammation than women free of diabetes. • Men and women with diabetes have evidence for high levels of angiogenic inhibition.