Inhibition of IL-6 family cytokines by SOCS3

• Published in: Seminars in immunology Vol. 26; no. 1; pp. 13 - 19
• Main Authors: Babon, Jeffrey J, Varghese, Leila N, Nicola, Nicos A
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-02-2014
• Subjects: Allergy and Immunology; Animals; Catalysis; Cytokine Receptor gp130 - metabolism; Cytokine signalling; Humans; IL-6; Interleukin-6 - antagonists & inhibitors; Interleukin-6 - metabolism; JAK/STAT; Janus Kinases; Janus Kinases - antagonists & inhibitors; Janus Kinases - metabolism; Models, Biological; Multigene Family; Protein Binding; Protein Interaction Domains and Motifs; Receptors, Interleukin-6 - metabolism; Signal Transduction; SOCS; Suppressor of Cytokine Signaling Proteins - chemistry; Suppressor of Cytokine Signaling Proteins - genetics; Suppressor of Cytokine Signaling Proteins - metabolism; Janus Kinases; CNTF; cardiotrophin 1; oncostatin M; extracellular-signal-regulated kinase; IL-27; CT-1; granulocyte colony-stimulating factor; JAK/STAT; interleukin-11; interleukin-10; interleukin-6; glycoprotein 130; mitogen-activated protein kinase; SHP2; interleukin-27; Src homology 2; PI3K; gp130; JAKs; Suppressor of Cytokine Signalling; OSM; LIF; SOCS; MAPK; IL-11; G-CSF; IL-6; IL-10; cillary neurotrophic factor; STAT; Cytokine signalling; kinase inhibitory region; Signal Transducers and Activators of Transcription; KIR; interleukin-6 receptor alpha-chain; SH2 domain containing phosphatase; leukemia inhibitory factor; SH2; IL-6Rα; phosphoinositide 3-kinase; ERK
• ISSN: 1044-5323; 1096-3618
• DOI: 10.1016/j.smim.2013.12.004

Highlights • SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes.