Comparison of post-operative complications in oral cancer treated with and without neoadjuvant chemotherapy

• Published in: Journal of pharmacy & bioallied science Vol. 15; no. 6; pp. 1116 - 1118
• Main Authors: Sarma, Mridul, Missong, Ajit, Sharma, Moitrayee, Debnath, Asim, Mahanta, Neelakshi, Choudhury, Mrinmoy
• Format: Journal Article
• Language: English
• Published: Mumbai Wolters Kluwer India Pvt. Ltd 01-07-2023; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Adjuvant treatment; Cancer; Chemotherapy; Complications; Complications and side effects; Mouth cancer; neoadjuvant chemotherapy; Oral cancer; Oral carcinoma; Oral squamous cell carcinoma; Original; Patients; Postoperative; Squamous cell carcinoma; Statistical analysis; Surgery; upfront surgery; Neoadjuvant chemotherapy; upfront surgery; oral squamous cell carcinoma; oral cancer
• ISSN: 0975-7406; 0976-4879; 0975-7406
• DOI: 10.4103/jpbs.jpbs_196_23

Aim: The aim of the present study was to compare the treatment outcome in oral cancer cases treated with neoadjuvant chemotherapy (NACT) and upfront surgery in localized advance disease. Materials and Methods: A randomized, prospective study was conducted in 20 cases. Patients were divided into two groups. Group A was taken up for upfront surgery and group B was taken up for surgery after two to three cycles of NACT based on patients' response, performance, and compliance. Results: Neither group showed statistically significant differences in clinical characteristics. In the present study, satisfactory outcomes were seen in nine patients belonging to NACT group and eight patients of non-NACT group had satisfactory outcomes after surgery, which were found to be statistically significant (P = 0.001). Conclusion: NACT may be considered as a treatment option for oral squamous cell carcinoma patients, particularly those with locally advanced tumors. Further prospective studies are needed to validate these findings in patients.