Discrete melanocortin-sensitive neuroanatomical pathway linking the ventral premmamillary nucleus to the paraventricular hypothalamus

• Published in: Neuroscience Vol. 240; pp. 70 - 82
• Main Authors: Gautron, L, Cravo, R.M, Elmquist, J.K, Elias, C.F
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 14-06-2013
• Subjects: Animals; beta-Endorphin - metabolism; Biotin - analogs & derivatives; Biotin - metabolism; Cholera Toxin - metabolism; Dextrans - metabolism; Female; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; leptin; Leptin - administration & dosage; Male; Mammillary Bodies - cytology; melanocortin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Neurological; mouse; Neural Pathways - physiology; Neurology; Neurons - cytology; Neurons - physiology; Odorants; Olfactory Pathways - physiology; Oncogene Proteins v-fos - metabolism; oxytocin; Paraventricular Hypothalamic Nucleus; Receptor, Melanocortin, Type 4 - genetics; Receptor, Melanocortin, Type 4 - metabolism; reproduction; STAT3 Transcription Factor - metabolism; tracing; ventral premammillary nucleus; PVH; biotin dextran amine; diaminobenzidine tetrahydrochloride; phosphate-buffered saline; CTb; GFP; mouse; PMv; PBS; tracing; oxytocin; DAB; cholera toxin b subunit; luteinizing hormone; paraventricular nucleus of the hypothalamus; leptin; melanocortin-4 receptor; phosphorylated-STAT3; pSTAT3; green-fluorescent protein; LH; BDA; MC4-R; melanocortin; reproduction
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2013.02.024

Highlights ► MC4-R-expressing neurons located in the PMv project to the mouse PVH. ► Melanocortin and PMv innervations converge onto oxytocin neurons. ► PMv MC4-R-expressing neurons are stimulated by sex odorants.