Rab1 in cell signaling, cancer and other diseases

• Published in: Oncogene Vol. 35; no. 44; pp. 5699 - 5704
• Main Authors: Yang, X-Z, Li, X-X, Zhang, Y-J, Rodriguez-Rodriguez, L, Xiang, M-Q, Wang, H-Y, Zheng, X F S
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03-11-2016; Nature Publishing Group
• Subjects: 631/80/86; Amino acids; Animals; Apoptosis; Cancer; Cardiomyopathies - genetics; Cardiomyopathies - metabolism; Cardiomyopathy; Carrier Proteins; Cell Biology; Cell migration; Cell signaling; Cell surface; Cellular biology; Cellular signal transduction; Cholesterol; Development and progression; Disease Susceptibility; Endoplasmic reticulum; Gene Expression Regulation, Neoplastic; Genetic aspects; Golgi apparatus; Human Genetics; Humans; Internal Medicine; Lipids; Medicine; Medicine & Public Health; Membrane trafficking; Membranes; Movement disorders; Neoplasms - genetics; Neoplasms - metabolism; Neurodegenerative diseases; Oncology; Parkinson's disease; Physiological aspects; Protein Binding; Protein Interaction Domains and Motifs; Protein transport; rab1 GTP-Binding Proteins - chemistry; rab1 GTP-Binding Proteins - genetics; rab1 GTP-Binding Proteins - metabolism; review; Signal Transduction; Therapeutic applications; United States; China
• ISSN: 0950-9232; 1476-5594
• DOI: 10.1038/onc.2016.81

The endoplasmic reticulum (ER) and Golgi membrane system have major roles in cell signaling and regulation of the biosynthesis/transport of proteins and lipids in response to environmental cues such as amino acid and cholesterol levels. Rab1 is the founding member of the Rab small GTPase family, which is known to mediate dynamic membrane trafficking between ER and Golgi. Growing evidence indicate that Rab1 proteins have important functions beyond their classical vesicular transport functions, including nutrient sensing and signaling, cell migration and presentation of cell-surface receptors. Moreover, deregulation of
RAB1
expression has been linked to a myriad of human diseases such as cancer, cardiomyopathy and Parkinson’s disease. Further investigating these new physiological and pathological functions of Rab1 should provide new opportunities for better understanding of the disease processes and may lead to more effective therapeutic interventions.