Prediction of pregnancy rate by blastocyst morphological score and age, based on 1,488 single frozen-thawed blastocyst transfer cycles

• Published in: Fertility and sterility Vol. 95; no. 3; pp. 948 - 952
• Main Authors: Goto, Sakae, M.D., Ph.D, Kadowaki, Takashi, M.D., M.P.H., Ph.D, Tanaka, Satomi, B.S, Hashimoto, Hiromi, B.S, Kokeguchi, Shoji, M.D., Ph.D, Shiotani, Masahide, M.D., Ph.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-03-2011; Elsevier
• Subjects: Adult; age; Age Factors; Biological and medical sciences; Cryopreservation; delivery rate; Delivery. Postpartum. Lactation; embryo score; Female; Fertilization in Vitro; frozen-thawed blastocyst; Gynecology. Andrology. Obstetrics; Humans; Internal Medicine; Medical sciences; Middle Aged; Obstetrics and Gynecology; Oocytes - cytology; Predictive Value of Tests; Pregnancy; Pregnancy Rate; Retrospective Studies; Single Embryo Transfer - methods; Single Embryo Transfer - statistics & numerical data; Single-blastocyst transfer; Young Adult; frozen-thawed blastocyst; embryo score; delivery rate; age; pregnancy rate; Single-blastocyst transfer; Embryo; Gynecology; Blastocyst; Thawing; Obstetrics; Freezing; Pregnancy; Delivery; Predictive factor; Age
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2010.06.067

Objective To present an estimation of the pregnancy rate after IVF or intracytoplasmic sperm injection stratified by blastocyst morphology and age. Design Retrospective analysis. Setting Private IVF clinic. Patient(s) A total of 1,488 single frozen-thawed blastocyst transfer cycles. Intervention(s) All frozen-thawed blastocysts used in the study were obtained in the patients' first oocytes retrieval cycles. Main Outcome Measure(s) Clinical pregnancy rate (CPR), viable pregnancy rate (VPR), and delivery rate (DR) according to blastocyst morphological score (Gardner and Schoolcraft score) in three different age groups: women aged 22–33 years, 34–37 years, and 38–45 years. Result(s) The quality of blastocysts degraded as age group increased. The proportions of good-quality blastocysts (grades 4 and above) were 62.3%, 56.3%, and 41.1% in age groups of 22–33 years, 34–37 years, and 38–45 years. Within the same blastocyst quality, CPR, VPR, and DR tended to be lower with increased age. Chances of pregnancy were reduced by 60% or more for women 38 years and older with blastocyst morphology of grades 1 and 2. Significant trends were observed for both age and blastocyst morphology groups. Conclusion(s) There was a significant correlation between blastocyst quality and CPR, VPR, and DR in addition to the influence of age on the three rates. The findings may help predict successful pregnancy in single-blastocyst transfer.