Role of myelin-associated inhibitors in axonal repair after spinal cord injury

• Published in: Experimental neurology Vol. 235; no. 1; pp. 33 - 42
• Main Authors: Lee, Jae K., Zheng, Binhai
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-05-2012
• Subjects: Animals; Axon guidance; Axon regeneration; Axonogenesis; Axons - metabolism; Central nervous system; Data processing; GPI-Linked Proteins - metabolism; MAG; Mice; Myelin; Myelin Proteins - metabolism; Myelin-Associated Glycoprotein - metabolism; Nerve Regeneration - physiology; NgR1; Nogo; Nogo protein; Nogo Proteins; Nogo receptor; Oligodendrocyte-myelin glycoprotein; OMgp; Regeneration; Spinal Cord Injuries - metabolism; Spinal cord injury; Sprouting; MAG; OMgp; Sprouting; Axon regeneration; Myelin; Nogo receptor; Spinal cord injury; Nogo; NgR1
• ISSN: 0014-4886; 1090-2430
• DOI: 10.1016/j.expneurol.2011.05.001

Myelin-associated inhibitors of axon growth, including Nogo, MAG and OMgp, have been the subject of intense research. A myriad of experimental approaches have been applied to investigate the potential of targeting these molecules to promote axonal repair after spinal cord injury. However, there are still conflicting results on their role in axon regeneration and therefore a lack of a cohesive mechanism on how these molecules can be targeted to promote axon repair. One major reason may be the lack of a clear definition of axon regeneration in the first place. Nevertheless, recent data from genetic studies in mice indicate that the roles of these molecules in CNS axon repair may be more intricate than previously envisioned.