Perioperative prophylaxis with ertapenem reduced infections caused by extended-spectrum betalactamase-producting Enterobacteriaceae after kidney transplantation

• Published in: BMC nephrology Vol. 20; no. 1; p. 274
• Main Authors: Sanclemente, Gemma, Bodro, Marta, Cervera, Carlos, Linares, Laura, Cofán, Frederic, Marco, Francesc, Bosch, Jordi, Oppenheimer, Federico, Dieckmann, Fritz, Moreno, Asunción
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22-07-2019; BioMed Central; BMC
• Subjects: Bacterial infections; Carbapenems; Causes of; Complications and side effects; Control; Dosage and administration; Drug therapy; Enterobacteriaceae; Enterobacteriàcies; Infection; Kidney transplantation; Multidrug-resistant bacteria; Patient outcomes; Surgical prophylaxis; Trasplantament renal; Spain; Infection; Surgical prophylaxis; Kidney transplantation; Multidrug-resistant bacteria
• ISSN: 1471-2369; 1471-2369
• DOI: 10.1186/s12882-019-1461-4

In recent years we have witnessed an increase in infections due to multidrug-resistant organisms in kidney transplant recipients (KTR). In our setting, we have observed a dramatic increase in infections caused by extended-spectrum betalactamase-producing (ESBL) Enterobacteriaceae in KTR. In 2014 we changed surgical prophylaxis from Cefazolin 2 g to Ertapenem 1 g.
We compared bacterial infections and their resistance phenotype during the first post-transplant month with an historical cohort collected during 2013 that had received Cefazolin.
During the study period 110 patients received prophylaxis with Cefazolin and 113 with Ertapenem. In the Ertapenem cohort we observed a non-statistically significant decrease in the percentage of early bacterial infection from 57 to 47%, with urine being the most frequent source in both. The frequency of infections caused by Enterobacteriaceae spp. decreased from 64% in the Cefazolin cohort to 36% in the Ertapenem cohort (p = 0.005). In addition, percentage of ESBL-producing strains decreased from 21 to 8% of all Enterobacteriaceae isolated (p = 0.015). After adjusted in multivariate Cox regression analysis, male sex (HR 0.16, 95%CI: 0.03-0.75), cefazolin prophylaxis (HR 4.7, 95% CI: 1.1-22.6) and acute rejection (HR 14.5, 95% CI: 1.3-162) were associated to ESBL- producing Enterobacteriaceae infection.
Perioperative antimicrobial prophylaxis with a single dose of Ertapenem in kidney transplant recipients reduced the incidence of early infections due to ESBL-producing Enterobacteriaceae without increasing the incidence of other multidrug-resistant microorganisms or C. difficile.