Inflammation and thrombosis in cardiovascular disease

PURPOSE OF REVIEWThis article will summarize recent observations that provide mechanistic insight into the molecular and cellular links between inflammation and thrombosis in the context of cardiovascular and other thromboinflammatory disease states. RECENT FINDINGSSeveral disease conditions are cha...

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Bibliographic Details
Published in:	Current opinion in hematology Vol. 20; no. 5; pp. 457 - 463
Main Authors:	Nagareddy, Prabhakara, Smyth, Susan S
Format:	Journal Article
Language:	English
Published:	United States Wolters Kluwer Health \| Lippincott Williams & Wilkins 01-09-2013
Subjects:	Animals Anti-Inflammatory Agents - therapeutic use Blood Platelets - physiology Cardiovascular Diseases - drug therapy Cardiovascular Diseases - physiopathology Fibrinolytic Agents - therapeutic use Humans Inflammation - physiopathology Neutrophils - physiology Thrombosis - physiopathology
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Summary:	PURPOSE OF REVIEWThis article will summarize recent observations that provide mechanistic insight into the molecular and cellular links between inflammation and thrombosis in the context of cardiovascular and other thromboinflammatory disease states. RECENT FINDINGSSeveral disease conditions are characterized by a thromboinflammatory state in which interactions of blood cells and components with the vascular wall perpetuate both thrombotic and inflammatory pathways. Targeting these pathways may be of benefit in inflammatory conditions and cardiovascular disease. SUMMARYOngoing clinical trials should provide additional insight into the hypothesis that the thromboinflammatory state contributes to adverse clinical outcomes.
ISSN:	1065-6251 1531-7048
DOI:	10.1097/MOH.0b013e328364219d