Synchrotron X-ray fluorescence studies of a bromine-labelled cyclic RGD peptide interacting with individual tumor cells

• Published in: Journal of synchrotron radiation Vol. 20; no. 2; pp. 226 - 233
• Main Authors: Sheridan, Erin J., Austin, Christopher J. D., Aitken, Jade B., Vogt, Stefan, Jolliffe, Katrina A., Harris, Hugh H., Rendina, Louis M.
• Format: Journal Article
• Language: English
• Published: 5 Abbey Square, Chester, Cheshire CH1 2HU, England International Union of Crystallography 01-03-2013; John Wiley & Sons, Inc
• Subjects: Animals; BASIC BIOLOGICAL SCIENCES; Bromine; CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; Fluorescence; Humans; Imaging; Instruments & Instrumentation; Lung Neoplasms - metabolism; Melanoma, Experimental - metabolism; Mice; microprobe; Neovascularization, Pathologic - prevention & control; Oligopeptides - chemistry; Oligopeptides - metabolism; Optics; OTHER INSTRUMENTATION; Peptides; Peptides, Cyclic - chemistry; Peptides, Cyclic - pharmacokinetics; Physics; Quantitative analysis; Research Papers; RGD peptide; Spectrometry, X-Ray Emission - methods; Synchrotron radiation; Synchrotrons; tumor cells; Tumor Cells, Cultured; Tumors; X-rays; XRF; tumor cells; XRF; RGD peptide; microprobe
• ISSN: 1600-5775; 0909-0495; 1600-5775
• DOI: 10.1107/S0909049513001647

The first example of synchrotron X‐ray fluorescence imaging of cultured mammalian cells in cyclic peptide research is reported. The study reports the first quantitative analysis of the incorporation of a bromine‐labelled cyclic RGD peptide and its effects on the biodistribution of endogenous elements (for example, K and Cl) within individual tumor cells.