Effect of Circulation Parameters on Functional Status of HepaRG Spheroids Cultured in Microbioreactor

We studied the relationship between microcirculation parameters and functional status of HepaRG cells in spheroids and chose an optimal regimen within the physiologically permissible limits of mechanical impact for the cells that maintains the expression of functional genes of the liver.

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Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 161; no. 3; pp. 425 - 429
Main Authors:	Semenova, O. V., Petrov, V. A., Gerasimenko, T. N., Aleksandrova, A. V., Burmistrova, O. A., Khutornenko, A. A., Osipyants, A. I., Poloznikov, A. A., Sakharov, D. A.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-07-2016 Springer Springer Nature B.V
Subjects:	Analysis Biomedical and Life Sciences Biomedicine Bioreactors Cell Biology Cell Survival - physiology Cells (Biology) Hepatocytes - cytology Humans Internal Medicine Laboratory Medicine Liver - cytology Methods Microcirculation - physiology Microfluidics Pathology HepaRG spheroids microcirculation liver-on-a-chip
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Summary:	We studied the relationship between microcirculation parameters and functional status of HepaRG cells in spheroids and chose an optimal regimen within the physiologically permissible limits of mechanical impact for the cells that maintains the expression of functional genes of the liver.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-016-3430-2