Kigamicins, novel antitumor antibiotics. II. Structure determination

Kigamicin A (1), B (2), C (3), D (4) and E (5) are novel antitumor antibiotics. Their structures were determined by spectroscopic analyses including various NMR measurements. Kigamicins have a unique aglycone of fused octacyclic ring system containing seven of six-membered rings and one oxazolidine....

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Bibliographic Details
Published in:	Journal of antibiotics Vol. 56; no. 12; p. 1012
Main Authors:	Kunimoto, Setsuko, Someno, Tetsuya, Yamazaki, Yohko, Lu, Jie, Esumi, Hiroyasu, Naganawa, Hiroshi
Format:	Journal Article
Language:	English
Published:	Japan 01-12-2003
Subjects:	Antibiotics, Antineoplastic - chemistry Doxorubicin - analogs & derivatives Doxorubicin - chemistry Magnetic Resonance Spectroscopy Molecular Structure Oxazoles - chemistry Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Infrared Spectrophotometry, Ultraviolet
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Summary:	Kigamicin A (1), B (2), C (3), D (4) and E (5) are novel antitumor antibiotics. Their structures were determined by spectroscopic analyses including various NMR measurements. Kigamicins have a unique aglycone of fused octacyclic ring system containing seven of six-membered rings and one oxazolidine. The aglycone links a sugar chain composed of one to four deoxysugars. These sugars were found to be amicetose and oleandrose.
ISSN:	0021-8820
DOI:	10.7164/antibiotics.56.1012