Physiological Parameters of Macaca Fascicularis Immunized with Anti-Rubella Vaccine with Germanium-Based Adjuvants

• Published in: Bulletin of experimental biology and medicine Vol. 157; no. 1; pp. 81 - 84
• Main Authors: Karal-ogly, D. D., Agrba, V. Z., Lavrent’eva, I. N., Ambrosov, I. V., Matelo, S. K., Chuguev, Yu. P., Gvaramiya, I. A., Gvozdik, T. E., Mukhametzyanova, E. I.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01-05-2014; Springer; Springer Nature B.V
• Subjects: Adjuvants, Immunologic - administration & dosage; Adjuvants, Immunologic - chemistry; Animals; Antibodies, Viral - blood; Biomedical and Life Sciences; Biomedicine; Blood Cell Count; Cell Biology; Drug Evaluation, Preclinical; Female; Germanium - chemistry; Germanium - immunology; Health aspects; Immunization; Immunoglobulin E - blood; Internal Medicine; Laboratory Medicine; Macaca fascicularis; Male; Measles-mumps-rubella vaccine; Organometallic Compounds - administration & dosage; Organometallic Compounds - chemistry; Organometallic Compounds - immunology; Pathology; Primatology; Rats; Rubella; Rubella - blood; Rubella - immunology; Rubella - prevention & control; Rubella - virology; Rubella Vaccine - administration & dosage; Rubella Vaccine - biosynthesis; Rubella Vaccine - immunology; Rubella virus; Rubella virus - immunology; Vaccination; Vaccines; Vaccines, Attenuated; Macaca fascicularis; hematology; adjuvant; biochemistry
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-014-2497-x

Clinical status, hematological and biochemical parameters, and allergenic activity of organogermanium compounds used as adjuvants in complex with preparation from Orlov rubella virus vaccine strain and reference commercial anti-rubella vaccine based on Wistar RA 27/3 strain were studied on
Macaca fascilcularis
of both genders. Physiological parameters of monkeys immunized with the Russian and foreign rubella virus vaccine strains with and without adjuvants did not differ. The adjuvants were inessential for the safety of vaccines (absence of toxicity, reactogenic activity, or allergenic activity) in preclinical studies on lower primates.