Membrane Vesicles as Drug Delivery Systems: Source, Preparation, Modification, Drug Loading, In Vivo Administration and Biodistribution, and Application in Various Diseases

• Published in: Pharmaceutics Vol. 15; no. 7; p. 1903
• Main Authors: Sun, Chenhan, Qin, Ying, Zhuang, Hongda, Zhang, Yuan, Wu, Zhiwen, Chen, Yong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-07-2023; MDPI
• Subjects: bacterial outer membrane vesicles (OMVs); Biodistribution; Blood; Cells; Drug delivery systems; drug delivery systems (DDSs); Drugs; exosomes; Extracellular vesicles; extracellular vesicles (EVs); membrane vesicles; Particle size; Probiotics; Vehicles; bacterial outer membrane vesicles (OMVs); extracellular vesicles (EVs); membrane vesicles; drug delivery systems (DDSs); exosomes
• ISSN: 1999-4923; 1999-4923
• DOI: 10.3390/pharmaceutics15071903

Bioinspired (or biologically inspired) drug delivery systems (DDSs) have been intensively studied in the last decades. As bioinspired DDSs, membrane vesicles, including extracellular vesicles (EVs) released from eukaryotic cells, outer membrane vesicles (OMVs) from bacteria, cell-bound membrane vesicles (CBMVs) isolated in situ from cell surfaces, membrane vesicles reorganized after the isolation of the plasma membrane of cells, and others have been rapidly developed and are attracting more and more attention. Most recently, a collection of 25 papers on the advances in membrane vesicle-based drug delivery systems was published in a Special Issue of
entitled "Advances of membrane vesicles in drug delivery systems". These papers cover many related topics including the source, preparation, modification, drug loading, and in vivo administration and biodistribution of membrane vesicles (mainly extracellular vesicles or exosomes and bacterial outer membrane vesicles), as well as application of membrane vesicles as DDSs in the treatment of various diseases.