Opiate-induced changes in brain adenosine levels and narcotic drug responses

• Published in: Neuroscience Vol. 228; pp. 235 - 242
• Main Authors: Wu, M, Sahbaie, P, Zheng, M, Lobato, R, Boison, D, Clark, J.D, Peltz, G
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 03-01-2013; Elsevier
• Subjects: Adenosine - metabolism; Analgesics; Analgesics, Opioid - pharmacology; Animals; Behavior, Addictive - genetics; Behavior, Addictive - metabolism; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Male; Medical sciences; metabolomic analysis; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Morphine - pharmacology; Morphine Dependence - genetics; Morphine Dependence - metabolism; Narcotics - pharmacology; Neurology; Neuropharmacology; opiates; Pharmacology. Drug treatments; Species Specificity; liquid chromatography with mass spectroscopy; PBS; tandem mass spectroscopy; metabolomic analysis; LC/MS/MS; Adk; phosphate-buffered saline; opiates; A 2a; LC/MS; adenosine kinase; A 1; adenosine A 2a receptor; adenosine A 1 receptor; A1; A2a; Vertebrata; Adenosine; Mammalia; Mouse; Animal; Rodentia; Central nervous system; Dependence; Opiates; Narcotic analgesic; Encephalon
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.10.031

Highlights ► Morphine decreased brainstem adenosine in morphine-dependent mice. ► Withdrawal was diminished in genetically engineered mice with reduced adenosine tone. ► Opiate-induced changes in adenosine may explain addiction-associated behaviors.