The association of diabetes and positive prostate biopsy in a US veteran population

• Published in: Prostate cancer and prostatic diseases Vol. 15; no. 1; pp. 70 - 74
• Main Authors: Moses, K A, Utuama, O A, Goodman, M, Issa, M M
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-03-2012; Nature Publishing Group
• Subjects: Aged; Analysis; Biomarkers, Tumor - blood; Biomedical and Life Sciences; Biomedicine; Biopsy; Cancer Research; Carcinogenesis; Carcinogens; Cohort Studies; Comorbidity; Confidence intervals; Demographic aspects; Development and progression; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - pathology; Diagnosis; Health aspects; Health care facilities; Humans; Logistic Models; Male; Middle Aged; original-article; Population studies; Prostate; Prostate - pathology; Prostate cancer; Prostate-Specific Antigen - blood; Prostatic Neoplasms - blood; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - epidemiology; Regression analysis; Regression models; Risk Factors; Statistical analysis; United States - epidemiology; Veterans; United States; prostate biopsy; diabetes mellitus; cancer
• ISSN: 1365-7852; 1476-5608
• DOI: 10.1038/pcan.2011.40

Background:
Several studies have shown a protective effect of diabetes mellitus (DM) on incidence of prostate cancer; however, the data are not consistent. Moreover, whether or not DM is associated with a positive result among patients referred for prostate biopsy due to abnormal PSA and/or abnormal digital rectal examination is not clear.
Methods:
A retrospective review of 3162 consecutive men who underwent prostate biopsy between January 2000 and July 2009 at the Atlanta Veterans Affairs Medical Center was performed. Men with positive and negative biopsies were compared for various demographic and clinical factors. The data were analyzed using logistic regression models with results expressed as adjusted odds ratios (ORs) with corresponding 95% confidence intervals (CI).
Results:
DM was associated with increased odds of positive biopsy in the overall cohort (OR 1.26, 95% CI: 1.01–1.55;
P
=0.04). Subjects with DM had higher odds of more aggressive disease (Gleason ⩾7) than those without the condition (OR 1.31, 95% CI: 0.98–1.74;
P
=0.07). Race had no significant impact on these results.
Conclusions:
In this large series of prostate biopsies, diabetes is associated with higher odds of positive biopsy and higher Gleason grade. More studies investigating the role of DM and its associated comorbidities in prostate carcinogenesis are needed.