Endothelial colony-forming cells reduced the lung injury induced by cardiopulmonary bypass in rats
Background Cardiopulmonary bypass (CPB) results in severe lung injury via inflammation and endothelial injury. The aim of this study was to evaluate the effect of endothelial colony-forming cells (ECFCs) on lung injury in rats subjected to CPB. Methods Thirty-two rats were randomized into the sham,...
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| Published in: | Stem cell research & therapy Vol. 11; no. 1; pp. 1 - 12 |
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| Abstract | Background Cardiopulmonary bypass (CPB) results in severe lung injury via inflammation and endothelial injury. The aim of this study was to evaluate the effect of endothelial colony-forming cells (ECFCs) on lung injury in rats subjected to CPB. Methods Thirty-two rats were randomized into the sham, CPB, CPB/ECFC and CPB/ECFC/L-NIO groups. The rats in the sham group received anaesthesia, and the rats in the other groups received CPB. The rats also received PBS, ECFCs and L-NIO-pre-treated ECFCs. After 24 h of CPB, pulmonary capillary permeability, including the PaO.sub.2/FiO.sub.2 ratio, protein levels in bronchoalveolar lavage fluid (BALF) and lung tissue wet/dry weight were evaluated. The cell numbers and cytokines in BALF and peripheral blood were tested. Endothelial injury, lung histological injury and apoptosis were assessed. The oxidative stress response and apoptosis-related proteins were analysed. Results After CPB, all the data deteriorated compared with those obtained in the S group (sham vs CPB vs CPB/ECFC vs CPB/ECFC/L-NIO: histological score 1.62 [+ or -] 0.51 vs 5.37 [+ or -] 0.91 vs 3.37 [+ or -] 0.89 vs 4.37 [+ or -] 0.74; PaO.sub.2/FiO.sub.2 389 [+ or -] 12 vs 233 [+ or -] 36 vs 338 [+ or -] 28 vs 287 [+ or -] 30; wet/dry weight 3.11 [+ or -] 0.32 vs 6.71 [+ or -] 0.73 vs 4.66 [+ or -] 0.55 vs 5.52 [+ or -] 0.57; protein levels in BALF: 134 [+ or -] 22 vs 442 [+ or -] 99 vs 225 [+ or -] 41 vs 337 [+ or -] 53, all P < 0.05). Compared to the CPB treatment, ECFCs significantly improved pulmonary capillary permeability and PaO.sub.2/FiO.sub.2. Similarly, ECFCs also decreased the inflammatory cell number and pro-inflammatory factors in BALF and peripheral blood, as well as the oxidative stress response in the lung tissue. ECFCs reduced the lung histological injury score and apoptosis and regulated apoptosis-related proteins in the lung tissue. Compared with the CPB/ECFC group, all the indicators were partly reversed by the L-NIO. Conclusions ECFCs significantly reduced lung injury induced by inflammation after CPB. Keywords: Endothelial colony-forming cells, Cardiopulmonary bypass, Inflammation, Lung injury |
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| AbstractList | Background Cardiopulmonary bypass (CPB) results in severe lung injury via inflammation and endothelial injury. The aim of this study was to evaluate the effect of endothelial colony-forming cells (ECFCs) on lung injury in rats subjected to CPB. Methods Thirty-two rats were randomized into the sham, CPB, CPB/ECFC and CPB/ECFC/L-NIO groups. The rats in the sham group received anaesthesia, and the rats in the other groups received CPB. The rats also received PBS, ECFCs and L-NIO-pre-treated ECFCs. After 24 h of CPB, pulmonary capillary permeability, including the PaO.sub.2/FiO.sub.2 ratio, protein levels in bronchoalveolar lavage fluid (BALF) and lung tissue wet/dry weight were evaluated. The cell numbers and cytokines in BALF and peripheral blood were tested. Endothelial injury, lung histological injury and apoptosis were assessed. The oxidative stress response and apoptosis-related proteins were analysed. Results After CPB, all the data deteriorated compared with those obtained in the S group (sham vs CPB vs CPB/ECFC vs CPB/ECFC/L-NIO: histological score 1.62 [+ or -] 0.51 vs 5.37 [+ or -] 0.91 vs 3.37 [+ or -] 0.89 vs 4.37 [+ or -] 0.74; PaO.sub.2/FiO.sub.2 389 [+ or -] 12 vs 233 [+ or -] 36 vs 338 [+ or -] 28 vs 287 [+ or -] 30; wet/dry weight 3.11 [+ or -] 0.32 vs 6.71 [+ or -] 0.73 vs 4.66 [+ or -] 0.55 vs 5.52 [+ or -] 0.57; protein levels in BALF: 134 [+ or -] 22 vs 442 [+ or -] 99 vs 225 [+ or -] 41 vs 337 [+ or -] 53, all P < 0.05). Compared to the CPB treatment, ECFCs significantly improved pulmonary capillary permeability and PaO.sub.2/FiO.sub.2. Similarly, ECFCs also decreased the inflammatory cell number and pro-inflammatory factors in BALF and peripheral blood, as well as the oxidative stress response in the lung tissue. ECFCs reduced the lung histological injury score and apoptosis and regulated apoptosis-related proteins in the lung tissue. Compared with the CPB/ECFC group, all the indicators were partly reversed by the L-NIO. Conclusions ECFCs significantly reduced lung injury induced by inflammation after CPB. Keywords: Endothelial colony-forming cells, Cardiopulmonary bypass, Inflammation, Lung injury Cardiopulmonary bypass (CPB) results in severe lung injury via inflammation and endothelial injury. The aim of this study was to evaluate the effect of endothelial colony-forming cells (ECFCs) on lung injury in rats subjected to CPB. Thirty-two rats were randomized into the sham, CPB, CPB/ECFC and CPB/ECFC/L-NIO groups. The rats in the sham group received anaesthesia, and the rats in the other groups received CPB. The rats also received PBS, ECFCs and L-NIO-pre-treated ECFCs. After 24 h of CPB, pulmonary capillary permeability, including the PaO.sub.2/FiO.sub.2 ratio, protein levels in bronchoalveolar lavage fluid (BALF) and lung tissue wet/dry weight were evaluated. The cell numbers and cytokines in BALF and peripheral blood were tested. Endothelial injury, lung histological injury and apoptosis were assessed. The oxidative stress response and apoptosis-related proteins were analysed. After CPB, all the data deteriorated compared with those obtained in the S group (sham vs CPB vs CPB/ECFC vs CPB/ECFC/L-NIO: histological score 1.62 [+ or -] 0.51 vs 5.37 [+ or -] 0.91 vs 3.37 [+ or -] 0.89 vs 4.37 [+ or -] 0.74; PaO.sub.2/FiO.sub.2 389 [+ or -] 12 vs 233 [+ or -] 36 vs 338 [+ or -] 28 vs 287 [+ or -] 30; wet/dry weight 3.11 [+ or -] 0.32 vs 6.71 [+ or -] 0.73 vs 4.66 [+ or -] 0.55 vs 5.52 [+ or -] 0.57; protein levels in BALF: 134 [+ or -] 22 vs 442 [+ or -] 99 vs 225 [+ or -] 41 vs 337 [+ or -] 53, all P < 0.05). Compared to the CPB treatment, ECFCs significantly improved pulmonary capillary permeability and PaO.sub.2/FiO.sub.2. Similarly, ECFCs also decreased the inflammatory cell number and pro-inflammatory factors in BALF and peripheral blood, as well as the oxidative stress response in the lung tissue. ECFCs reduced the lung histological injury score and apoptosis and regulated apoptosis-related proteins in the lung tissue. Compared with the CPB/ECFC group, all the indicators were partly reversed by the L-NIO. ECFCs significantly reduced lung injury induced by inflammation after CPB. Abstract Background Cardiopulmonary bypass (CPB) results in severe lung injury via inflammation and endothelial injury. The aim of this study was to evaluate the effect of endothelial colony-forming cells (ECFCs) on lung injury in rats subjected to CPB. Methods Thirty-two rats were randomized into the sham, CPB, CPB/ECFC and CPB/ECFC/L-NIO groups. The rats in the sham group received anaesthesia, and the rats in the other groups received CPB. The rats also received PBS, ECFCs and L-NIO-pre-treated ECFCs. After 24 h of CPB, pulmonary capillary permeability, including the PaO2/FiO2 ratio, protein levels in bronchoalveolar lavage fluid (BALF) and lung tissue wet/dry weight were evaluated. The cell numbers and cytokines in BALF and peripheral blood were tested. Endothelial injury, lung histological injury and apoptosis were assessed. The oxidative stress response and apoptosis-related proteins were analysed. Results After CPB, all the data deteriorated compared with those obtained in the S group (sham vs CPB vs CPB/ECFC vs CPB/ECFC/L-NIO: histological score 1.62 ± 0.51 vs 5.37 ± 0.91 vs 3.37 ± 0.89 vs 4.37 ± 0.74; PaO2/FiO2 389 ± 12 vs 233 ± 36 vs 338 ± 28 vs 287 ± 30; wet/dry weight 3.11 ± 0.32 vs 6.71 ± 0.73 vs 4.66 ± 0.55 vs 5.52 ± 0.57; protein levels in BALF: 134 ± 22 vs 442 ± 99 vs 225 ± 41 vs 337 ± 53, all P < 0.05). Compared to the CPB treatment, ECFCs significantly improved pulmonary capillary permeability and PaO2/FiO2. Similarly, ECFCs also decreased the inflammatory cell number and pro-inflammatory factors in BALF and peripheral blood, as well as the oxidative stress response in the lung tissue. ECFCs reduced the lung histological injury score and apoptosis and regulated apoptosis-related proteins in the lung tissue. Compared with the CPB/ECFC group, all the indicators were partly reversed by the L-NIO. Conclusions ECFCs significantly reduced lung injury induced by inflammation after CPB. Background Cardiopulmonary bypass (CPB) results in severe lung injury via inflammation and endothelial injury. The aim of this study was to evaluate the effect of endothelial colony-forming cells (ECFCs) on lung injury in rats subjected to CPB. Methods Thirty-two rats were randomized into the sham, CPB, CPB/ECFC and CPB/ECFC/L-NIO groups. The rats in the sham group received anaesthesia, and the rats in the other groups received CPB. The rats also received PBS, ECFCs and L-NIO-pre-treated ECFCs. After 24 h of CPB, pulmonary capillary permeability, including the PaO2/FiO2 ratio, protein levels in bronchoalveolar lavage fluid (BALF) and lung tissue wet/dry weight were evaluated. The cell numbers and cytokines in BALF and peripheral blood were tested. Endothelial injury, lung histological injury and apoptosis were assessed. The oxidative stress response and apoptosis-related proteins were analysed. Results After CPB, all the data deteriorated compared with those obtained in the S group (sham vs CPB vs CPB/ECFC vs CPB/ECFC/L-NIO: histological score 1.62 ± 0.51 vs 5.37 ± 0.91 vs 3.37 ± 0.89 vs 4.37 ± 0.74; PaO2/FiO2 389 ± 12 vs 233 ± 36 vs 338 ± 28 vs 287 ± 30; wet/dry weight 3.11 ± 0.32 vs 6.71 ± 0.73 vs 4.66 ± 0.55 vs 5.52 ± 0.57; protein levels in BALF: 134 ± 22 vs 442 ± 99 vs 225 ± 41 vs 337 ± 53, all P < 0.05). Compared to the CPB treatment, ECFCs significantly improved pulmonary capillary permeability and PaO2/FiO2. Similarly, ECFCs also decreased the inflammatory cell number and pro-inflammatory factors in BALF and peripheral blood, as well as the oxidative stress response in the lung tissue. ECFCs reduced the lung histological injury score and apoptosis and regulated apoptosis-related proteins in the lung tissue. Compared with the CPB/ECFC group, all the indicators were partly reversed by the L-NIO. Conclusions ECFCs significantly reduced lung injury induced by inflammation after CPB. |
| ArticleNumber | 246 |
| Audience | Academic |
| Author | Ju, Yingnan Sun, Haibin Xu, Guangxiao Zhao, Xiaoqing Tai, Qihang Gao, Wei |
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| CitedBy_id | crossref_primary_10_2147_JIR_S365970 crossref_primary_10_3389_fcvm_2022_1000761 crossref_primary_10_1186_s12872_023_03664_3 crossref_primary_10_1186_s13287_021_02567_4 crossref_primary_10_1080_14779072_2022_2149492 crossref_primary_10_1186_s12872_024_03909_9 |
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| Snippet | Background Cardiopulmonary bypass (CPB) results in severe lung injury via inflammation and endothelial injury. The aim of this study was to evaluate the effect... Cardiopulmonary bypass (CPB) results in severe lung injury via inflammation and endothelial injury. The aim of this study was to evaluate the effect of... Abstract Background Cardiopulmonary bypass (CPB) results in severe lung injury via inflammation and endothelial injury. The aim of this study was to evaluate... |
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| SubjectTerms | Alveoli Anesthesia Apoptosis Bronchus Cardiopulmonary bypass Catheters Cell number Colonies Colony-forming cells Coronary artery bypass Cytokines Endothelial colony-forming cells Endothelium Experiments Heart surgery Inflammation Laboratory animals Lung injury Lungs Medical research Membrane permeability Microscopy Oxidative stress Peripheral blood Permeability Proteins Rodents Studies Veins & arteries Ventilation |
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| Title | Endothelial colony-forming cells reduced the lung injury induced by cardiopulmonary bypass in rats |
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