Epitope diversification driven by non-tumor epitope-specific Th1 and Th17 mediates potent antitumor reactivity

• Published in: Vaccine Vol. 30; no. 43; pp. 6190 - 6197
• Main Authors: Ichikawa, Kosuke, Kagamu, Hiroshi, Koyama, Kenichi, Miyabayashi, Takao, Koshio, Jun, Miura, Satoru, Watanabe, Satoshi, Yoshizawa, Hirohisa, Narita, Ichiei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 21-09-2012; Elsevier Limited
• Subjects: Allergy and Immunology; Animals; Antibodies; Antigen (tumor-associated); Antigen Presentation; Antigens, Neoplasm - immunology; Antitumor activity; Apoptosis; Autocrine Communication; Autocrine signalling; Bone marrow; CD4 antigen; CD4-positive T-lymphocytes; CD8 antigen; CD8-positive T-lymphocytes; Cell Line, Tumor; Cytotoxicity; Dendritic Cells; Dendritic Cells - immunology; Diversification; Epitopes; Epitopes, T-Lymphocyte - immunology; Experiments; Female; Fibrosarcoma - immunology; Helper cells; Humans; IL-23; immunity; Immunoregulation; Immunotherapy; Interleukin 23; Interleukin-23 - immunology; Laboratories; Lymphocytes; Lymphocytes T; Major histocompatibility complex; Mice; Mice, Inbred C57BL; Mice, Transgenic; patients; Peptides; T-Lymphocytes, Regulatory - immunology; Th1 Cells - immunology; Th17; Th17 Cells - immunology; Th2 Cells - immunology; Tumor cells; Tumor immunity; Tumors; Vaccination; vaccines; Japan; Tumor immunity; Dendritic Cells; IL-23; Th17
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2012.07.060

Highlights ► Non tumor-specific CD4+ T cells can induce tumor antigen presentation by DC. ► Th1 and Th17, but not Th2 facilitated diverse tumor antigen presentation. ► Autocrine of IL-23 by DC plays a critical role in diverse tumor antigen presentation. ► Diverse tumor antigen presentation resulted in potent antitumor immunity in vivo.