Fibroin-Gelatin Composite Stimulates the Regeneration of a Splinted Full-Thickness Skin Wound in Mice

• Published in: Bulletin of experimental biology and medicine Vol. 168; no. 1; pp. 95 - 98
• Main Authors: Arkhipova, A. Yu, Kulikov, D. A., Moisenovich, A. M., Andryukhina, V. V., Chursinova, Yu. V., Filyushkin, Yu. N., Fedulov, A. V., Bobrov, M. A., Mosalskaya, D. V., Glazkova, P. A., Kulikov, A. V., Nalivkin, A. E., Molochkov, A. V., Semenov, D. Yu
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-11-2019; Springer; Springer Nature B.V
• Subjects: Analysis; Animals; Appendages; Biomedical and Life Sciences; Biomedicine; Biotechnologies; Care and treatment; Cell Biology; Connective tissues; Contraction; Epidermis; Fibroins - chemistry; Fibroins - pharmacology; Follicles; Gelatin; Gelatin - chemistry; Gelatin - pharmacology; Internal Medicine; Laboratory Medicine; Male; Mice; Mice, Inbred C57BL; Microparticles; Pathology; Regeneration - drug effects; Sebaceous gland; Skin; Skin - drug effects; Skin - metabolism; Skin Diseases - drug therapy; Topical Collection on Gun Violence; Wound healing; Wound Healing - drug effects; Wounds and injuries; splinted full-thickness skin wound in mouse; fibroin; regeneration; gelatin
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-019-04656-0

The effects of composite fibroin-gelatin microparticles (100-250 μ) on the rate of wound healing and regeneration under conditions of contraction prevention were studied on the model of splinted full-thickness skin wound in a mouse. Subcutaneous injection of these particles into the defect area accelerated wound healing and promoted re-epithelialization and recovery of normal structure of the epidermis. In addition, the composite microparticles promoted the formation of connective tissue of characteristic structure, replacing the derma over the entire defect, and stimulated regeneration of subcutaneous muscle (panniculus carnosus) and skin appendages (sebaceous glands and hair follicles).