Protocol for the systematic review and meta-analysis of factors associated with non-adherence to antidepressants in depressive disorders in those more than 18 years of age

• Published in: PloS one Vol. 18; no. 2; p. e0281366
• Main Authors: Dhungana, Saraswati, Rijal, Rojal, Regmi, Binit, Bajracharya, Jala Shree, Sharma, Subriddhi, Singh, Sunil, Karn, Nilam, Chapagai, Manisha
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06-02-2023; Public Library of Science (PLoS)
• Subjects: Adolescent; Age; Analysis; Antidepressants; Antidepressants, Tricyclic; Antidepressive Agents - therapeutic use; Bias; Cardiovascular disease; Clinical trials; Comorbidity; Complications and side effects; Depression - drug therapy; Depression, Mental; Depressive Disorder - drug therapy; Drug therapy; Evaluation; Health risks; Humans; Intervention; Medicine and Health Sciences; Mental depression; Mental disorders; Meta-analysis; Meta-Analysis as Topic; Patient compliance; Patient outcomes; Patients; Physical Sciences; Prescription drugs; Quality of Life; Registered Report Protocol; Research and Analysis Methods; Systematic review; Systematic Reviews as Topic; Nepal
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0281366

We have developed a protocol for the systematic review and meta-analysis of the factors associated with nonadherence to antidepressants in depressive patients more than 18 years of age.
We will search articles with the databases PubMed- Medline, Scopus, Embase and PsychINFO. All the published literature reporting factors associated with nonadherence to antidepressants in depressive disorders in patients more than 18 years of age and fulfilling all the eligibility criteria till October 2022 will be included. The data will then be extracted and examined to be included in the systematic review. Finally, we will conduct meta-analysis for factors associated with non-adherence.
We will do extensive search on the proposed topic within the available literature and come up with a robust review of factors associated with nonadherence to antidepressants in patients age more than 18 years globally. The evidence generated would assist in designing interventions to address non-adherence in this group of patients leading to better productivity and quality of life.