Primary Cerebral Neuroblastoma: A Case Report and Review

• Published in: The Tohoku Journal of Experimental Medicine Vol. 197; no. 1; pp. 55 - 65
• Main Authors: ETUS, VOLKAN, KURTKAYA, ÖZLEM, SAV, AYDIN, ILBAY, KONURALP, CEYLAN, SAVAS
• Format: Journal Article
• Language: English
• Published: Japan Tohoku University Medical Press 01-05-2002
• Subjects: Biopsy, Needle; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - pathology; Brain Neoplasms - therapy; Chemotherapy, Adjuvant; Child; childhood supratentorial tumors; Combined Modality Therapy; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Immunohistochemistry; Neuroblastoma - diagnostic imaging; Neuroblastoma - pathology; Neuroblastoma - therapy; Neuroectodermal Tumors, Primitive - diagnostic imaging; Neuroectodermal Tumors, Primitive - pathology; neuropathological differential diagnosis; Neurosurgical Procedures - methods; primary cerebral neuroblastoma; primitive neuroepithelial tumors; Radiotherapy, Adjuvant; Risk Assessment; Tomography, X-Ray Computed; Treatment Outcome
• ISSN: 0040-8727; 1349-3329
• DOI: 10.1620/tjem.197.55

Primitive neuroepithelial tumors are the least common among supratentorial tumors in children. They pose great diagnostic difficulty, preoperatively as well as pathologically. Being quite rare, cerebral neuroblastomas are accepted as a distinct pathological entity, which differs from other neuroectodermal tumors, although clinically, radiologically, and morphologically at operation they are indistinguishable. Also differentiation between primary cerebral neuroblastoma and the other primitive neuroectodermal tumors may be difficult on light microscopy and be misleading. A 9-year-old girl with primary cerebral neuroblastoma who was initially misdiagnosed is reported. The other cases from the literature are reviewed and the nature of this rare tumor and its differential diagnosis is discussed.