Patient Blood Management in Liver Transplant-A Concise Review

Transfusion of blood products in orthotopic liver transplantation (OLT) significantly increases post-transplant morbidity and mortality and is associated with reduced graft survival. Based on these results, an active effort to prevent and minimize blood transfusion is required. Patient blood managem...

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Bibliographic Details
Published in:	Biomedicines Vol. 11; no. 4; p. 1093
Main Authors:	Pérez-Calatayud, Angel Augusto, Hofmann, Axel, Pérez-Ferrer, Antonio, Escorza-Molina, Carla, Torres-Pérez, Bettina, Zaccarias-Ezzat, Jed Raful, Sanchez-Cedillo, Aczel, Manuel Paez-Zayas, Victor, Carrillo-Esper, Raul, Görlinger, Klaus
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-04-2023 MDPI
Subjects:	Acidosis adult and pediatric liver transplant Anemia Anticoagulants Blood platelets Blood products Blood transfusion Blood transfusions Clinical outcomes coagulation Hepatitis C Hypertension Immunological tolerance Kidneys Liver Liver cirrhosis Liver diseases Liver transplantation Liver transplants Morbidity Mortality patient blood management Patients Plasma Proteins Review Thrombocytopenia Thrombosis Transplantation viscoelastic testing Viscoelasticity United States patient blood management viscoelastic testing coagulation adult and pediatric liver transplant
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Summary:	Transfusion of blood products in orthotopic liver transplantation (OLT) significantly increases post-transplant morbidity and mortality and is associated with reduced graft survival. Based on these results, an active effort to prevent and minimize blood transfusion is required. Patient blood management is a revolutionary approach defined as a patient-centered, systematic, evidence-based approach to improve patient outcomes by managing and preserving a patient's own blood while promoting patient safety and empowerment. This approach is based on three pillars of treatment: (1) detecting and correcting anemia and thrombocytopenia, (2) minimizing iatrogenic blood loss, detecting, and correcting coagulopathy, and (3) harnessing and increasing anemia tolerance. This review emphasizes the importance of the three-pillar nine-field matrix of patient blood management to improve patient outcomes in liver transplant recipients.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	2227-9059 2227-9059
DOI:	10.3390/biomedicines11041093