A Causal Relationship Between Type 1 Diabetes and Risk of Osteoporosis: A Univariable and Multivariable Mendelian Randomization Study

• Published in: Journal of diabetes research Vol. 2024; pp. 1610688 - 6
• Main Authors: Qin, Hailin, Yang, Kui, Wang, Hufei, Jiao, Wenyong
• Format: Journal Article
• Language: English
• Published: England Hindawi 08-05-2024; Hindawi Limited
• Subjects: Causality; Diabetes; Diabetes Mellitus, Type 1 - epidemiology; Diabetes Mellitus, Type 1 - genetics; Disease; Fractures; Genetic Predisposition to Disease; Genome-Wide Association Study; Genomes; Humans; Insulin resistance; Mendelian Randomization Analysis; Metabolism; Obesity; Observational studies; Osteoporosis; Osteoporosis - epidemiology; Osteoporosis - genetics; Polymorphism, Single Nucleotide; Risk Factors; Vitamin D - analogs & derivatives; Vitamin D - blood; osteoporosis; type 1 diabetes; Mendelian randomization study
• ISSN: 2314-6745; 2314-6753
• DOI: 10.1155/2024/1610688

Objective: This Mendelian randomization (MR) analysis aims to investigate the causal relationship between type 1 diabetes (T1D) and osteoporosis (OP).Methods: Single nucleotide polymorphisms (SNPs) associated with T1D were selected from the summary statistics of the genome-wide association study (GWAS) in European ancestry as instrumental variables (IVs) for univariable MR (UVMR) to explore the causal relationship between T1D and OP. Inverse variance weighting (IVW) was the primary method used to assess possible causality between T1D and OP. MR-PRESSO and MR-Egger intercepts were used to assess the horizontal pleiotropy of the IVs, and Q tests and the “leave-one-out” method were used to test for heterogeneity of MR results. Multivariable MR (MVMR) analysis was used to account for potential confounders such as smoking, obesity, drinking, and serum 25-hydroxyvitamin D (25OHD) concentrations.Result: Inverse variance weighted estimates suggest T1D may increase risk of OP (UVMR: OR=1.06, 95% CI: 1.02–1.10, p=0.002) (MVMR: OR=1.50, 95% CI: 1.07–1.90, p<0.001).Conclusion: Our findings suggest that T1D can increase the risk of OP.