Novel Biomarkers for Early Detection of Acute Kidney Injury and Prediction of Long-Term Kidney Function Decline after Partial Nephrectomy

• Published in: Biomedicines Vol. 11; no. 4; p. 1046
• Main Authors: Allinovi, Marco, Sessa, Francesco, Villa, Gianluca, Cocci, Andrea, Innocenti, Samantha, Zanazzi, Maria, Tofani, Lorenzo, Paparella, Laura, Curi, Dritan, Cirami, Calogero Lino, Campi, Riccardo, Mari, Andrea, Ognibene, Agostino, Lorubbio, Maria, Fanelli, Alessandra, Romagnoli, Stefano, Romagnani, Paola, Minervini, Andrea
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28-03-2023; MDPI
• Subjects: acute kidney injury; Analysis; Biological markers; Biomarkers; Creatinine; Cystatin C; Diabetes; Epidermal growth factor receptors; Gelatinase; Hypertension; Kidney diseases; Kidneys; Leukocytes (neutrophilic); Lipocalin; Medical research; Medicine, Experimental; Nephrectomy; NephroCheck; NGAL; partial nephrectomy; Patients; Proteinuria; Regression analysis; Renal cell carcinoma; Robotic surgery; Robotics; Surgery; Urine; NGAL; TIMP-2; renal cell carcinoma; biomarkers; NephroCheck; IGFBP7; acute kidney injury; partial nephrectomy
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines11041046

Identifying acute kidney injury (AKI) within few hours of onset is certainly helpful. However, early prediction of a long-term eGFR decline may be an even more important goal. Our aim was to identify and compare serum [creatinine, kineticGFR, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL)] and urinary (NephroCheck, NGAL, proteinuria, albuminuria, acantocytes at urinary sediment) predictors of AKI that might efficiently predict long-term GFR decline after robotic Nephron-Spearing Surgery (rNSS).
Monocentric prospective observational study. Patients scheduled for rNSS for suspected localized Renal Cell Carcinoma from May 2017 to October 2017 were enrolled. Samples were collected preoperatively and postoperatively (timepoints: 4 h, 10 h, 24 h, 48 h), while kidney function was re-assessed up to 24 months.
38 patients were included; 16 (42%) developed clinical AKI. The eGFR decline at 24 months was more pronounced after postoperative AKI (-20.75 vs. -7.20,
< 0.0001). KineticGFR at 4 h (
= 0.008) and NephroCheck at 10 h (
= 0.001) were, at multivariable linear regression analysis, efficient predictors of post-operative AKI and long-term eGFR decline if compared to creatinine (R2 0.33 vs. 0.04).
NephroCheck and kineticGFR have emerged as promising noninvasive, accurate, and early biomarkers of postoperative AKI and long-term GFR decline after rNSS. Combining NephroCheck and kineticGFR in clinical practice would allow to identify high risk of postoperative AKI and long-term GFR decline as early as 10 h after surgery.