Unlocking the Secrets: Exploring the Biochemical Correlates of Suicidal Thoughts and Behaviors in Adults with Autism Spectrum Conditions

• Published in: Biomedicines Vol. 11; no. 6; p. 1600
• Main Authors: Cremone, Ivan Mirko, Nardi, Benedetta, Amatori, Giulia, Palego, Lionella, Baroni, Dario, Casagrande, Danila, Massimetti, Enrico, Betti, Laura, Giannaccini, Gino, Dell'Osso, Liliana, Carpita, Barbara
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31-05-2023; MDPI
• Subjects: Autism; autism spectrum disorder; Biomarkers; Blood levels; brain derived neurotrophic factor; Brain research; Cerebrospinal fluid; Cytokines; Genomes; Homocysteine; Inflammation; Interleukin 6; Kynurenic acid; Mental disorders; Nervous system; Neurobiology; Neurotrophic factors; Pathophysiology; Prognosis; Risk factors; Suicidal behavior; Suicide; Suicides & suicide attempts; Tryptophan; homocysteine; brain derived neurotrophic factor; serotonin; kynurenine pathway; suicidality; inflammation; biomarkers; autism spectrum disorder; interleukin-6; suicidal behavior; tryptophan
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines11061600

Involving 1 million people a year, suicide represents one of the major topics of psychiatric research. Despite the focus in recent years on neurobiological underpinnings, understanding and predicting suicide remains a challenge. Many sociodemographical risk factors and prognostic markers have been proposed but they have poor predictive accuracy. Biomarkers can provide essential information acting as predictive indicators, providing proof of treatment response and proposing potential targets while offering more assurance than psychological measures. In this framework, the aim of this study is to open the way in this field and evaluate the correlation between blood levels of serotonin, brain derived neurotrophic factor, tryptophan and its metabolites, IL-6 and homocysteine levels and suicidality. Blood samples were taken from 24 adults with autism, their first-degree relatives, and 24 controls. Biochemical parameters were measured with enzyme-linked immunosorbent assays. Suicidality was measured through selected items of the MOODS-SR. Here we confirm the link between suicidality and autism and provide more evidence regarding the association of suicidality with increased homocysteine (0.278) and IL-6 (0.487) levels and decreased tryptophan (-0.132) and kynurenic acid (-0.253) ones. Our results suggest a possible transnosographic association between these biochemical parameters and increased suicide risk.