Six cases of leprosy associated with allogeneic hematopoietic SCT

• Published in: Bone marrow transplantation (Basingstoke) Vol. 40; no. 9; pp. 859 - 863
• Main Authors: PIERONI, F, STRACIERI, A. B. P. L, VIGORITTO, A. C, TRABASSO, P, SOUZA, C. A, DE SOUZA, M. P, MAUAD, M. A, COLTURATO, V. A. R, SIMOES, B. P, FOSS, N. P, VOLTARELLI, J. C, MORAES, D. A, PATON, E. J. A, SAGGIORO, F. P, BARROS, G. M. N, BARROS, J. C, OLIVEIRA, M. C. B, COUTINHO, M. A, CASTRO, N. S
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01-11-2007
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Bacterial diseases; Biological and medical sciences; Bone marrow, stem cells transplantation. Graft versus host reaction; Case studies; Complications and side effects; Diagnosis; Diagnosis, Differential; Differential diagnosis; Female; Graft versus host reaction; Hematopoietic Stem Cell Transplantation - adverse effects; Hematopoietic stem cells; Histocompatibility antigen HLA; Human bacterial diseases; Humans; Infectious diseases; Leprosy; Leprosy - diagnosis; Leprosy - etiology; Leprosy - pathology; Male; Medical sciences; Methods; Peripheral nerves; Peripheral Nervous System Diseases - diagnosis; Peripheral Nervous System Diseases - etiology; Risk factors; Skin Diseases - diagnosis; Skin Diseases - etiology; Stem cell transplantation; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplantation; Transplantation, Homologous; Treatment Outcome; Tropical bacterial diseases; Brazil; Infection; Skin disease; Hematology; Stem cell; allogeneic; stem cell transplantation; Bacteriosis; Hematopoietic cell; Homograft; Leprosy; Graft; Mycobacterial infection
• ISSN: 0268-3369; 1476-5365
• DOI: 10.1038/sj.bmt.1705824

We report here the first six cases of leprosy associated with HLA-identical allogeneic SCT in different phases and with different findings and outcomes. Skin and peripheral nerves may be sites of leprosy associated with SCT, stressing the importance of differential diagnosis between leprosy and GVHD or drug reactions. Clinical manifestations of leprosy before or after transplantation did not influence the outcome of SCT in our cases.