Perinatal outcomes in 375 children born after oocyte donation: a Danish national cohort study

• Published in: Fertility and sterility Vol. 99; no. 6; pp. 1637 - 1643.e3
• Main Authors: Malchau, Sara S., M.D, Loft, Anne, M.D, Larsen, Elisabeth C., M.D., Ph.D, Aaris Henningsen, Anna-Karina, M.D, Rasmussen, Steen, M.Sc, Andersen, Anders Nyboe, M.D., D.M.Sci, Pinborg, Anja, M.D., D.M.Sci
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-05-2013
• Subjects: Adult; Assisted reproduction; Child; children; Cohort Studies; conception; congenital abnormalities; Denmark - epidemiology; egg donation; Female; gestational age; Humans; Infant, Newborn; Internal Medicine; intracytoplasmic sperm injection; low birth weight; obstetric outcome; Obstetrics and Gynecology; odds ratio; oocyte donation; Oocyte Donation - methods; Oocyte Donation - trends; oocytes; patients; Perinatal Care - methods; Perinatal Care - trends; perinatal outcome; pre-eclampsia; preeclampsia; Pregnancy; Pregnancy Outcome - epidemiology; premature birth; preterm birth; risk; twins; Denmark; preterm birth; obstetric outcome; low birth weight; preeclampsia; Assisted reproduction; egg donation; perinatal outcome; oocyte donation
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2013.01.128

Objective To describe perinatal outcomes in children born after oocyte donation (OD) compared with in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and spontaneous conception (SC). Design National cohort study. Setting Fertility clinics. Patient(s) Three hundred seventy-five children born after OD during the period 1995–2010. Intervention(s) None. Main Outcome Measure(s) Mean birth weight, mean gestational age, risks of low birth weight (LBW), preterm birth (PTB), congenital malformations, cesarean delivery, preeclampsia, and admittance to neonatal intensive care unit. Result(s) We found an increased risk of PTB in OD pregnancies. The adjusted odds ratio (AOR) of PTB in OD singletons was 1.8 (95% CI, 1.2–2.69), 2.5 (95% CI, 1.7–3.6), and 3.4 (95% CI, 2.3–4.9) compared with IVF, ICSI, and SC, respectively. The risk of LBW was also increased. The AOR of LBW was 1.4 (95% CI, 0.9–2.2), 1.8 (95% CI, 1.2–2.8), and 2.6 (95% CI, 1.7–4.0) compared with IVF, ICSI, and SC. The risk of preeclampsia was increased in OD pregnancies with an AOR of 2.9 (95% CI, 1.8–4.6), 2.8 (95% CI, 1.7–4.5), and 3.1 (95% CI, 1.9–4.9) compared with IVF, ICSI, and SC. After additional adjustment for preeclampsia, perinatal outcome improved. Among the twins, the difference between the groups was less pronounced. Conclusion(s) Pregnancies after OD have a poorer perinatal outcome than those after standard IVF and ICSI mainly because of the high prevalence of preeclampsia.