Recent developments in bio-scaffold materials as delivery strategies for therapeutics for endometrium regeneration

• Published in: Materials today bio Vol. 11; p. 100101
• Main Authors: Li, X., Lv, H.-F., Zhao, R., Ying, M.-f., Samuriwo, A.T., Zhao, Y.-Z.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-06-2021; Elsevier
• Subjects: Asherman's syndrome/endometrium regeneration; Biological scaffold material; Review; Scaffold-based therapeutics delivery systems; Stem cell; Therapeutic factor; Biological scaffold material; D&C; dEMSCs; Therapeutic factor; UCMSCs; Stem cell; MSC-Sec; VEGF; KGF; Asherman's syndrome/endometrium regeneration; bFGF; ECM; IUA; BMNCs; SDF-1α; Scaffold-based therapeutics delivery systems; hESCs; BMSCs; En-PSC
• ISSN: 2590-0064; 2590-0064
• DOI: 10.1016/j.mtbio.2021.100101

Intrauterine adhesions (IUAs) refer to the repair disorder after endometrial injury and may lead to uterine infertility, recurrent miscarriage, abnormal menstrual bleeding, and other obstetric complications. It is a pressing public health issue among women of childbearing age. Presently, there are limited clinical treatments for IUA, and there is no sufficient evidence that these treatment modalities can effectively promote regeneration after severe endometrial injury or improve pregnancy outcome. The inhibitory pathological micro-environment is the main factor hindering the repair of endometrial damaged tissues. To address this, tissue engineering and regenerative medicine have been achieving promising developments. Particularly, biomaterials have been used to load stem cells or therapeutic factors or construct an in situ delivery system as a treatment strategy for endometrial injury repair. This article comprehensively discusses the characteristics of various bio-scaffold materials and their application as stem cell or therapeutic factor delivery systems constructed for uterine tissue regeneration.
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