Guinea Pig Maximization Test of Tri-ethylene Glycol Mono-methacrylate

• Published in: Dental Materials Journal Vol. 26; no. 3; pp. 312 - 315
• Main Authors: AKIYAMA, Takashi, MANABE, Atsufumi, TANI, Chihiro, TAKAHASHI, Yoichi, ITOH, Kazuo, HISAMITSU, Hisashi
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society for Dental Materials and Devices 2007
• Subjects: Allergic reaction; Animals; Dentin primer; Dentin-Bonding Agents - adverse effects; Drug Eruptions - etiology; Glycerides - adverse effects; Guinea Pigs; Methacrylates - adverse effects; Polyethylene Glycols - adverse effects; Polymethacrylic Acids - adverse effects; tri-ethylene glycol mono-methacrylate
• ISSN: 0287-4547; 1881-1361
• DOI: 10.4012/dmj.26.312

The aim of this study was to evaluate tri-ethylene glycol mono-methacrylate (TEGMA) in terms of dermatological allergic reaction using a Guinea Pig Maximization Test. Skin reaction was evaluated according to the criteria of International Contact Dermatitis Research Group. TEGMA, as a constituent in new primers, has been reported to contribute to a priming ability similar to that of highly purified glyceryl mono-methacrylate (GM). In this study, it was found that its adverse effect was less than that of 2-hydroxy ethyl methacrylate (2-HEMA), but similar to that of highly purified GM. In conclusion, it was anticipated that TEGMA would hereafter replace 2-HEMA as a primer, as it posed a lower risk of triggering dermatological allergic reaction.