Loss of heterozygosity at loci from chromosome arm 22Q in human sporadic breast carcinomas

• Published in: International journal of cancer Vol. 75; no. 2; pp. 181 - 186
• Main Authors: Allione, Florence, Eisinger, François, Parc, Patricia, Noguchi, Tetsuro, Sobol, Hagay, Birnbaum, Daniel
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 19-01-1998; Wiley-Liss
• Subjects: Biological and medical sciences; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Chromosomes, Human, Pair 22; Female; Gynecology. Andrology. Obstetrics; Humans; Loss of Heterozygosity; Mammary gland diseases; Medical sciences; Middle Aged; Tumors; Chromosomal aberration; Human; Carcinoma; Sporadic; Malignant tumor; Carcinogenesis; Mammary gland diseases; Loss of heterozygosity; Abnormal chromosome G22; Cytogenetics; Deletion; Abnormal chromosome; Genetics; Mammary gland
• ISSN: 0020-7136; 1097-0215
• DOI: 10.1002/(SICI)1097-0215(19980119)75:2<181::AID-IJC3>3.0.CO;2-Q

Forty‐four breast carcinomas were studied for loss of heterozygosity (LOH) at 25 microsatellite markers distributed almost evenly along chromosome arm 22q. LOH at at least one marker were observed in 66% tumors, while 6 regions of consistent LOH were identified. The size of each region ranged between 3 and 6 cM, and the distance between each region was estimated to be 8 to 12 cM. Even if not all these regions contain a bona fide tumor‐suppressor gene, it is possible that several loci from chromosome arm 22q may be involved in breast carcinogenesis. Int. J. Cancer 75:181–186, 1998. © 1998 Wiley‐Liss, Inc.